摘要
G蛋白偶联受体(GPCRs)在机体内有显著的免疫调节的介导作用。近年来的研究发现,GPCRs在电针干预类风湿关节炎的炎性疼痛效应机制中起着重要作用,其中肾上腺素受体、5-羟色胺受体、腺苷受体、阿片肽受体、多巴胺受体和大麻素受体等诸多受体在中枢神经系统、外周神经系统和炎症局部都分别介导电针对关节炎大鼠炎性疼痛的影响。对电针促进GPCRs表达增加的发生机制的探讨是我们今后研究的方向。
G protein coupled receptors （GPCRs） have a marked mediating effect on bodily immunoregulation. Recent years＇ studies found that GPCRs plays an important role in the mechanism of the intervening effect of electroacupuncture on rheumatoid arthritis pain. Of them, adrcnergic receptors, 5-hydroxytryptamine receptors, adenosine receptors, opioid peptide receptors, dopamine receptors and cannabinoid receptors separately mediate the effect of electroacupuncture on rheumatoid arthritis pain in the central and peripheral nervous systems and the inflammatory region. The exploration of the mechanism by which electroacupuncture increases GPCRs expression is our future research direction.
出处
《上海针灸杂志》
2015年第3期273-276,共4页
Shanghai Journal of Acupuncture and Moxibustion
基金
上海市中医药事业发展三年行动计划(重大研究)(ZYSNXD-CCZDYJ052)
上海市科委资助项目(12401904100)
关键词
针刺疗法
电针
关节炎
类风湿
炎性疼痛
G蛋白偶联受体
Acupuncture therapy
Arthritis, rheumatoid
Inflammatory pain
G protein coupled receptors
