摘要
[目的]探讨谷氨酰胺(glutamine,Gln)结合酪酸梭菌二联活菌胶囊对肝硬化患者肠屏障及肝功能的改善作用。[方法]选取80例肝硬化患者,将其平均分为Gln组、益生菌组、Gln与益生菌结合组(结合组)、对照组,观察其相关治疗后的肠屏障功能指标及肝功能指标。[结果]Gln组、益生菌组、结合组患者的AST、ALT水平、ChildPugh评分均明显低于对照组(P<0.05),且结合组均低于Gln组和益生菌组(P<0.05)。Gln组、益生菌组、结合组血清内毒素水平、DAO、TNF-α水平均较对照组显著下降,且结合组又较Gln组、益生菌组低。[结论]Gln结合酪酸梭菌二联活菌散能够有效改善肝硬化患者的肠屏障及肝功能,值得在临床上推广使用。
[Objective]To investigate the effects of glutamine（Gln）combined with clostridium butyricum on improving intestinal barrier and liver function in patients with liver cirrhosis.[Methods]Eighty patients with liver cirrhosis were randomly divided into Gln group,living bacteria group,combination group and control group.The intestinal barrier function and liver function were compared after treatment.[Results]In the Gln group,living bacteria group and combination group,the AST,ALT,Child-Pugh scores were significantly lower than those in the control group（P〈0.05）.The combination group were lower than those in Gln group and living bacteria group（P〈0.05）.In the Gln group,living bacteria group and combination group,the serum endotoxin,DAO,TNF-αlevels were significantly lower than those in the control group.The combination group were lower than those in Gln group and living bacteria group（P〈0.05）.[Conclusion]Gln combined with Clostridium butyricum could effectively improve intestinal barrier and liver function in patients with liver cirrhosis.
出处
《临床消化病杂志》
2015年第1期16-19,共4页
Chinese Journal of Clinical Gastroenterology
关键词
肝硬化
谷氨酰胺
酪酸梭菌二联活菌
肠屏障
liver cirrhosis
glutamine
clostridium butyricum
intestinal barrier
