摘要
目的:研究阿昔洛韦联合微波治疗对女性复发性生殖器疱疹患者炎性因子和免疫功能的影响。方法:将90例女性复发性生殖器疱疹患者纳入研究对象,根据治疗方法不同随机分为观察组和对照组,各45例,观察组患者接受阿昔洛韦联合微波治疗,对照组患者接受阿昔洛韦治疗,比较两组患者治疗效果、炎症因子含量以及免疫功能指标。结果:观察组有效率明显高于对照组(91.11%vs.73.33%);白介素-4、6(IL-4、IL-6)、肿瘤坏死因子-a(TNF-α)含量均明显低于对照组[(11.84±1.85)pg/mL vs.(18.95±2.58)pg/mL,(9.17±1.07)pg/mL vs.(15.68±1.85)pg/mL,(23.53±2.61)pg/mL vs.(44.18±6.89)pg/mL];CD4+、IgA、IgM、IgG明显高于对照组(41.28±2.94 vs.34.49±3.42,13.25±1.69 vs.7.94±0.95,2.55±0.36 vs.1.84±0.23,1.12±0.15 vs.0.74±0.08),CD8+水平明显低于对照组(21.46±3.37 vs.29.48±3.24)。结论:阿昔洛韦联合微波治疗有助于缓解炎症反应、提高机体细胞免疫和体液免疫功能,提高治疗效果。
Objective：To study the effect of acyclovir combined with microwave therapy on inflammatory factors and immune function of female patients with recurrent genital herpes.Methods：A total of 90 female cases of recurrent genital herpe were randomly divided into observation group and control group.In observation group patients received acyclovir combined with microwave therapy,patients of control group received acyclovir therapy.Then therapeutic effect,inflammatory factor and immune function indexes were compared.Results：In observation group efficient was significantly higher than that control group（91.11% vs 73.33%）;IL 4,IL-6,TNF-αlevels were significantly lower than control group[（11.84±1.85）pg/mLvs（18.95±2.58）pg/mL,（9.17±1.07）pg/mL vs（15.68±1.85）pg/mL,（23.53±2.61）pg/mL,（44.18±6.89）pg/mL];CD4＋,IgA,IgM and IgG were significantly higher than control group（41.28±2.94 vs34.49±3.42,13.25±1.69 vs 7.94±0.95,2.55±0.36 vs1.84±0.23,1.12±0.15 vs 0.74±0.08）,CD8＋levels was significantly lower than control group（21.46±3.37 vs 29.48±3.24）.Conclusion：Acyclovir combined with microwave therapy is helpful to alleviate inflammatory reaction,enhance cellular immunity and humoral immune function,improve the effect of treatment.
出处
《海南医学院学报》
CAS
2015年第4期520-522,526,共4页
Journal of Hainan Medical University
基金
国家医学教育发展中心资助项目(201-05-31-081)~~
关键词
复发性生殖器疱疹
阿昔洛韦
微波
炎症因子
免疫功能
Recurrent genital herpes
Acyclovir
Microwave
Inflammatory cytokines
Immune function
