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Efficacy and Safety of Tripterygium wilfordii Hook F Versus Acitretin in Moderate to Severe Psoriasis Vulgaris:A Randomized Clinical Trial 被引量:14

Efficacy and Safety of Tripterygium wilfordii Hook F Versus Acitretin in Moderate to Severe Psoriasis Vulgaris:A Randomized Clinical Trial
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摘要 Background:Few clinical trials have evaluated the efficacy and safety of Tripterygium wilfordii Hook F (TwHF) compared with acitretin in psoriasis.We aimed to compare the efficacy and safety of TwHF compared with acitretin in the treatment of moderate to severe psoriasis vulgaris.Methods:Adults with Psoriasis Area Severity Index (PASI) score > 10 and psoriasis-affected body surface area > 10% were randomized into a TwHF (20 mg,3 times a day) or acitretin group (30 mg,once a day).The treatment course lasted for 8 weeks.Patients were assessed at baseline and at 2,4,and 8 weeks.Laboratory tests were performed at baseline,week 4,and week 8.The data were analyzed using paired samples t-test or analysis of variance (ANOVA).Results:A total of 115 patients was enrolled (58 TwHF; 57 acitretin).The median PASI score improved in the TwHF group by 50.4% and in the acitretin group by 42.7%.There was no significant difference in median PASI improvement between two groups at 2,4,and 8 weeks.There was also no significant difference in PASI 25,PASI 50,PASI 75,and PASI 90 response between the two groups at 2,4,and 8 weeks.There was a significant increase in the level of aspartate transaminase and triglycerides in the TwHF group (P =0.026 and P =0.011,respectively).In the acitretin group,there was a significant increase in the level of alanine transaminase,cholesterol,and high-density lipoprotein (P =0.030,P < 0.01,and P < 0.01,respectively).Conclusions:There was no significant difference in treatment efficacy between the TwHF and acitretin groups within 8 weeks,but there were fewer treatment-related adverse events in the TwHF group. Background:Few clinical trials have evaluated the efficacy and safety of Tripterygium wilfordii Hook F (TwHF) compared with acitretin in psoriasis.We aimed to compare the efficacy and safety of TwHF compared with acitretin in the treatment of moderate to severe psoriasis vulgaris.Methods:Adults with Psoriasis Area Severity Index (PASI) score > 10 and psoriasis-affected body surface area > 10% were randomized into a TwHF (20 mg,3 times a day) or acitretin group (30 mg,once a day).The treatment course lasted for 8 weeks.Patients were assessed at baseline and at 2,4,and 8 weeks.Laboratory tests were performed at baseline,week 4,and week 8.The data were analyzed using paired samples t-test or analysis of variance (ANOVA).Results:A total of 115 patients was enrolled (58 TwHF; 57 acitretin).The median PASI score improved in the TwHF group by 50.4% and in the acitretin group by 42.7%.There was no significant difference in median PASI improvement between two groups at 2,4,and 8 weeks.There was also no significant difference in PASI 25,PASI 50,PASI 75,and PASI 90 response between the two groups at 2,4,and 8 weeks.There was a significant increase in the level of aspartate transaminase and triglycerides in the TwHF group (P =0.026 and P =0.011,respectively).In the acitretin group,there was a significant increase in the level of alanine transaminase,cholesterol,and high-density lipoprotein (P =0.030,P < 0.01,and P < 0.01,respectively).Conclusions:There was no significant difference in treatment efficacy between the TwHF and acitretin groups within 8 weeks,but there were fewer treatment-related adverse events in the TwHF group.
出处 《Chinese Medical Journal》 SCIE CAS CSCD 2015年第4期443-449,共7页 中华医学杂志(英文版)
关键词 ACITRETIN PSORIASIS Tripterygium wilfordii Hook F Acitretin Psoriasis Tripterygium wilfordii Hook F
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