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糖原合成酶激酶-3参与神经保护的研究进展

Progress of Neuroprotective Effects of Glycogen Synthase Kinase-3
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摘要 糖原合成酶激酶-3(GSK-3)是一种丝氨酸/苏氨酸蛋白激酶,有两种亚型,即GSK-3α和GSK-3β。GSK-3的活性受磷酸化和非磷酸化机制调节,可以磷酸化多种蛋白质,参与细胞分化、凋亡等多种生理过程的调节。GSK-3与脑缺血、阿尔茨海默病及其他神经精神疾病的发生都有关。 Glycogen synthase kinase-3（GSK-3） is a serine/threonine kinase,with two distinct forms termed GSK-3α and GSK-3β.Its activation is regulated by both phosphorylation and nonphosphorylation mechanisms.GSK-3 is implicated in the regulation of many physiological responses in mammalian cells by phosphorylating substrates.GSK-3 has been found involved in various neurologic diseases such as cerebral ischemia,Alzheimer＇s disease.
作者 文国强 刘涛
机构地区 海南省人民医院神经内科
出处 《中国临床神经科学》 2015年第1期82-87,共6页 Chinese Journal of Clinical Neurosciences
基金 国家自然科学基金地区基金项目(编号:81260204) 海南省重点科技计划项目(编号:ZDXM20120048) 海口市重点科技计划项目(编号:2012-066)
关键词 糖原合成酶激酶-3 神经保护 脑缺血 阿尔茨海默病 glycogen synthase kinase-3 neuroprotection cerebral ischemia Alzheimer＇s disease
分类号 R749.1 [医药卫生—神经病学与精神病学]
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中国临床神经科学
2015年 第1期

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