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迷走神经电刺激临床应用及机制研究进展 被引量：17

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摘要 迷走神经电刺激（vagus nerve stimulation,VNS）是指用一种可植入装置刺激迷走神经的治疗方法,即通过外科手术将螺旋电极缠绕于颈部内迷走神经上,将刺激装置埋在胸前,调整装置参数与模式,使刺激器自动刺激迷走神经达到治疗目的。迄今为止,全世界已有5万多例患者接受了这种治疗,主要应用于难治性癫痫和持续性、复发性抑郁,此外,VNS对记忆功能障碍、脑外伤、脑缺血的改善作用也得到越来越多的关注和研究。然而，这些治疗作用机制还不明晰。本文现将迷走神经解剖学和生理学特点、VNS方法、常见的临床应用和可能机制及在康复医学中应用前景综述如下。
作者 魏天祺 冯珍
机构地区 南昌大学第一附属医院
出处 《中国康复医学杂志》 CAS CSCD 北大核心 2015年第2期185-188,共4页 Chinese Journal of Rehabilitation Medicine
基金 国家自然科学基金(81260295)
关键词 迷走神经电刺激 复发性抑郁 难治性癫痫 螺旋电极 记忆功能障碍 刺激器 外科手术 STIMULATION 脑缺血 装置参数
分类号 R745 [医药卫生—神经病学与精神病学]
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  • 1Clark KB, Krahl SE, Smith DC, et al. Post-training unilateral vagal stimulation enhances retention performance in the rat. Neurobiol Learn Mem, 1995, 63 :213 -216.
  • 2Clark KB, Naritoku DK, Smith DC, et al. Enhanced recognition memory following vagus nerve stimulation in human subjects. Nature Neurosci, 1999, 2 : 94 -98.
  • 3Dedeurwaerdere S, Gilby K, Vonck K, et al. Vagus nerve stimulation does not affect spatial memory in fast rats, but has both anti-convulsive and pro-convulsive effects on amyg-dala-kindled seizures. Neuroscience, 2006, 140 : 1443-1451.
  • 4Ghacibeh GA, Shenker JI, Shenal B, et al. Effect of vagus nerve stimulation on creativity and cognitive flexibility. Epilepsy Behav, 2006, 8 : 720-725.
  • 5Zuo Y, Smith DC, Jensen RA. Vagus nerve stimulation potentiates hippocampal LTP in freely-moving rats. Physiol Behay, 2007, 90 : 583- 589.
  • 6Smith DC, Modglin AA, Roosevelt RW, et al. Electrical stimulation of the vagus nerve enhances cognitive and motor recovery following moderate fluid percussion injury in the rat. J Neurotrauma, 2005, 22 : 1485 -1502.
  • 7Merrill CA, Jonsson MA, Minthon L, et al. Vagus nerve stimulation in patients with Alzheimer's disease: Additional follow-up results of a pilot study through 1 year. J Clin Psychiatry, 2006, 67 : 1171- 1178.
  • 8Gibbs ME, Hutchinson DS, Summers R J, et al. Role of beta-Adrenoceptors in Memory Consolidation : beta( 3 ) -Adreno- ceptors Act on Glucose Uptake and beta (2)-Adrenoceptors on Glycogenolysis. Neuropsychopharmacology, 2008, 33 : 2384 - 2397.
  • 9Xu XY, Gao J, Wang TH, et al. Biofeedback treatment of prehypertension: analyses of efficacy, heart rate variability and EEG approximate entropy. J Hum Hypertens, 2007, 21 : 973 -975.
  • 10Sinha S,Patil SA,Jayalekshmy V,et al.Do cytokines have any role in epilepsy?[J].Epilepsy Res,2008,82(2-3):171-176.

共引文献13

同被引文献146

  • 1刘延青,刘文兴,王琼,余铣雄,康妹娟.应用HANS辅助硬膜外麻醉预防剖宫产内脏牵拉痛的临床研究[J].中国疼痛医学杂志,1996,2(4):215-216. 被引量：6
  • 2Javaid N, Imre J, Vatten LJ, et al. Temporal changes in resting heart rate and deaths from isehemic heart disease [ J ]. JAMA,2011,306 (23) :2579-2587.
  • 3Kaplon-Cieslicka A,Balsam P,Ozierafiski K,et aL Resting heart rate at hospital admission and its relation to hospital outcome in patients with heart failure[J]. J Cardio1,2014,21 (4) :425-433.
  • 4Ilaria C ,Gaetano P,Marianna L,et al. Prognostic role of heart rate variability in patients with ST-segment elevation acute myocardial infarction treated by primary angioplasty [ J]. Cardiology ,2013,124( 1 ) :63-70.
  • 5Schlaepfer TE, Frick C, Zobel A, et al. Vagus nerve stimulation for depression : efficacy and safety in a European study [ J ]. Psychol Med, 2008,38 ( 5 ) : 651- 661.
  • 6Hauptman PJ,Schwartz PJ,Gold MR,et al. Rationale and study design of the in- crease of vagal T on E in heart failure study : INOVATE-HF [ J ]. Am Heart J, 2012,163 (6) :954-962.
  • 7Clancy JA, Mary DA, Witte KK, et al. Non-invasive vagus nerve stimulation in healthy humans reduces sympathetic nerve activity [ J ]. Brain Stimul, 2014,7 (6) :871-877.
  • 8Zhao M, He X, Bi XY, et al. Vagal stimulation triggers peripheral vascular pro- tection through the cholinergic anti-inflammatory pathway in a rat model of myo- cardial ischemia/reperfusionl J]. Basic Res Cardiol, 2013,108(3) :1-16.
  • 9Sabbah HN. Electrical vagus nerve stimulation for the treatment of chronic heart failure[ J]. Cleve Clin J Med, 2011,78 ( 1 ) :783-789.
  • 10Drexel T, Eickhoh C, Mtlhlsteff J, et 81. Vagal heart rate control in patients with atrial fibrillation: impact of tonic activation of peripheral chemosensory func- tion in heart failure[J]. Adv Exp Med Biol,2013,755(755) :287-297.

引证文献17

二级引证文献67

中国康复医学杂志
2015年 第2期

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