摘要
目的对比分析成都地区城市和农村慢性阻塞性肺疾病（chronic obstructive pulmonary disease,COPD）患病情况及其危险因素差异。方法采取整群随机抽样方法,于2010年2~12月选取成都市城市和农村共4个社区,对被选人群中所有40~70岁居民进行问卷调查、体格检查和便携式肺功能检查。对气流受限者使用支气管扩张剂后再次测定一秒钟用力呼气量/用力肺活量（FEV1/FVC）小于70%者确诊为COPD。结果在1 931个样本人群中1 579人完成了调查表和肺功能检查,应答率81.77%。成都地区COPD总患病率8.35%,城市患病率7.69%低于农村12.37%（P〈0.05）;总患病率和男性患病率均随年龄增长而增加（P〈0.05）。单因素比较分析城市和农村COPD危险因素显示,农村COPD患者现在吸烟率和厨房烹饪用煤燃料比例高于城市患者（P〈0.05）,农村COPD患者体质量指数（body mass index,BMI）、腰围、文化教育程度以及家庭人均月收入均低于城市患者（P〈0.05）。多因素分析显示,吸烟量、文化程度、年龄和BMI是男性COPD危险因素。厨房烹饪燃料用煤、经济收入和BMI是女性COPD危险因素。结论成都地区COPD患病率高,农村高于城市,主要危险因素有吸烟量、厨房烹饪燃料、BMI。
Objective To determine risk factors associated with the prevalence of chronic obstructive pulmonary disease（COPD）in urban and rural populations in Chengdu.Methods A multistage random cluster sampling method was adopted to select participants from four communities in Chengdu.All residents aged 40-70 yr.were eligible to participate in this study,which involved a questionnaire survey,physical examination and portable spirometry.Those with airflow limitations were also given post-bronchodilator testing 15 min after inhalation of a dose of 200μg salbutamol.We defined a forced expiratory volume in one second/forced vital capacity（FEV1/FVC）of less than 70% as COPD.Logistic regression models were performed to identify risk factors of COPD.ResultsOf a total of 1 931 eligible participants,1 579（81.77%）completed the questionnaire and spirometry.About 8.35%were identified with COPD：7.69%in urban vs.12.37%in rural（P〈0.05）.The prevalence of COPD increased with age（P〈0.05）in the male and total populations.Rural COPD patients had a higher level of smoking rate and use of coal as fuel for cooking than their urban counterparts（P〈0.05）.But rural COPD patients had a lower level of BMI,waist circumference,literacy,and average household income per capita than their urban counterparts（P〈0.05）.The multivariate analysis showed that tobacco smoking index（pack-year）,education,age and BMI were predictors of COPD for male patients;whereas,coal fuel usage,income and BMI were predictors of COPD for female patients.Conclusion COPD prevalence is higher in rural areas than in urban Chengdu.Major risk factors of COPD include smoking,coal fuels and BMI.
出处
《四川大学学报（医学版）》
CAS
CSCD
北大核心
2015年第2期258-262,共5页
Journal of Sichuan University(Medical Sciences)
基金
卫生部前瞻性城乡流行病学研究(PURE)课题(No.312080222)资助
关键词
慢性阻塞性肺疾病
城乡
患病率
危险因素
肺功能
Chronic obstructive pulmonary disease
Urban and rural
Spirometry
Risk factors
Lung function
