摘要
目的:血浆B型利钠肽、心肌肌钙蛋白I、心肌酶评估有机磷中毒伴发心肌损害的价值。方法:128例有机磷中毒伴发心肌损害患者为有机磷中毒组,并根据中毒程度分为轻度中毒亚组41例,中度中毒亚组47例,重度中毒亚组40例。32例健康者作为对照组,给以受试者常规治疗后第1、3、5、7天进行静脉取血,检测血浆B型利钠肽和血清心肌肌钙蛋白I、心肌酶浓度。结果:四个时间点有机磷中毒组患者血浆B型利钠肽和血清心肌肌钙蛋白I、心肌酶浓度均显著高于对照组(P<0.05);有机磷中毒组患者随着中毒程度的加深,血浆B型利钠肽和血清心肌肌钙蛋白I、心肌酶浓度随之显著性增高(P<0.05)。结论:血浆B型利钠肽和血清心肌肌钙蛋白I、心肌酶浓度随着有机磷中毒程度的加深而不断增大,可用于有机磷中毒并发心肌损害的及时、有效的诊断和评估。
Objective： To evaluate the diagnostic value of blood levels of brain natriuretic peptide （BNP）, cardiac troponin （CTNI） and myocardial enzyme in patients with acute organic phosphorous poisoning （AOPP） combing myocardial injury.
Methods： A total of 128 AOPP patients with myocardial injury were divided into 3 groups according to poisoning level： Mild poisoning group, n=41, Moderate poisoning group, n-47 and Severe poisoning group, n=40. There was a Control group including 32 healthy subjects. All patients received conventional therapy and the blood levels of BNP, CTNI, myocardial enzyme were examined and compared among different groups at 1, 3, 5, 7 days after treatment.
Results： Compared with Control group, all AOPP patients had increased blood levels of BNP, CTNI and myocardial enzyme at different time points, all P〈0.05. The blood levels of BNP, CTNI and myocardial enzyme elevated with the increased AOPP level accordingly, all P〈0.05.
Conclusion： Blood levels of BNP, CTNI and myocardial enzyme gradually elevating with the severity of AOPP combined myocardial injury, and the above indexes could be used for the comprehensive and effective diagnosis in relevant patients.
出处
《中国循环杂志》
CSCD
北大核心
2015年第3期264-267,共4页
Chinese Circulation Journal
基金
衡水市科技基金项目(11026A)
关键词
有机磷中毒
心肌损害
B型利钠肽
心肌肌钙蛋白
心肌酶
Acute organic phosphorous poisoning
Myocardial injury
Brain natriuretic peptide
Cardiac troponin
Myocardial enzyme
