摘要
目的:评价不同手术方式治疗翼状胬肉的效果,并观察其对泪膜稳定性的影响。方法:选取翼状胬肉患者120例120眼,按照手术方式分为三组,每组各40例40眼。比较各组间术前、术后Shirmer试验(ShirmerⅠtest,SⅠt)和泪膜破裂时间(tear break-up time,BUT),角膜荧光素染色(corneal fluorescein staining,CFS)及术后复发率,评估手术疗效和对泪膜功能的影响。结果:术后1mo A组BUT较术前无显著差异;B组和C组较术前的变化有显著差异(P<0.05),但两组之间差异无统计学意义;术后1mo,三组SⅠt和术前比较差异均无统计学意义;术后1mo,A组与B组及C组CFS存在显著性差异(P<0.05);但B组和C组差异无统计学意义。术后3mo,A组BUT较术前无显著差异;B组及C组较术前有显著性差异(P<0.05),但B组及C组间差异无统计学意义;术后3mo,A组S I t较术前无显著差异;B组及C组S I t较术前有显著性差异(P<0.05),但两组间差异无统计学意义;术后3mo,A组术前与B组及C组CFS无显著差异。随访10mo,经比较A组与B、C两组复发率存在显著差异(P<0.05),B组与C组存在差异,但无统计学意义。夏季手术较冬季手术更容易复发。结论:翼状胬肉切除联合角膜缘干细胞移植封闭Tenon囊是目前治疗翼状胬肉的较理想手术方式,降低复发率并使患者泪膜功能得到一定程度的改善。
AIM： To compare the therapeutic effects of different surgical methods in treating pterygium patients and to observe tear film stability.METHODS： A total of 120 pterygium patients（ 120 eyes）were divided into three groups,each 40 cases（ 40 eyes）.Data including SchirmerⅠtest（ SⅠt）,tear break- up time（ BUT）,corneal fluorescein staining（ CFS） were recorded preoperatively and postoperatively to evaluate the clinical efficacy of surgery and the effects of tear function changes.RESULTS： There were no significant differences in BUT in group A before the operation and one month after operation. Groups B and C showed significant difference before and after operation, but differences were not statistically significant（ all P〈0. 05）; One month after operation,there was significant difference in CFS among group A,B and C（ P〈0. 05）,but the difference was not satistically significant between groups B and C; After3 mo,BUT in group A was not significant difference compared with the preoperative; but there was significant difference in groups B and C（ P〈0. 05）.When compared it between groups B and C, there showed no significant difference; Group A showed no significant difference in S Ⅰ t compared with preoperative,S Ⅰ t of groups B and C were significant differences compared with preoperative（ P〈0. 05）,but no significant difference between the two groups; After3 mo,CFS of preoperative group A and group B and group C had no significant difference. After 10 mo follow- up,there was axsignificant difference（ P〈0. 05） in recurrence rate in group A comparing with groups B and C,there were differences between groups B and C,but no statistically significant. Surgery is more likely to relapse in summer than in winter.CONCLUSION： Pterygium excision combined with self-corneal limbal stem cell transplantation and Tenon capsule closed is an ideal surgical to reduce the recurrence and improve tear film function to some extent.
出处
《国际眼科杂志》
CAS
2015年第3期558-561,共4页
International Eye Science
关键词
翼状胬肉
手术治疗
泪膜
角膜缘干细胞移植
pterygium
surgical methods
tear film
corneal limbal stem cell transplantation
