摘要
目的：探讨胆囊癌发病的相关危险因素,为有效预防和控制胆囊癌的发生提供理论依据。方法：回顾性分析2008年1月―2013年3月西安交通大学第一附属医院肝胆外科收治的802例胆囊癌患者资料,并以同期收治的815例非胆囊癌患者（排除与研究变量有明显相关的人群及病种）为对照,采用病例对照研究方法,分析胆囊癌发病相关危险因素分析。结果：经单因素分析选择自变量后,再行Logistic多因素分析,结果显示,年龄（50-70岁）、职业（农民）、体质量指数（≥27）、生育次数（≥3次）、绝经年龄（〉50岁）、血型（A型）、胆囊结石及慢性胆囊炎病史是胆囊癌发生的独立危险因素（均P〈0.05）。结论：以上因素可供临床结合具体病例参考,以利于胆囊癌的早期发现及早期治疗。
Objective： To determine the relevant factors in pathogenesis of gallbladder cancer, so as to provide a theoretical reference for preventing and controlling the development of this disease.Methods： The clinical records of 802 patients with gallbladder cancer（gallbladder cancer group） admitted to the Department of hepatobiliary surgery, the First Affiliated Hospital of Medical College of Xian Jiaotong University from February 2008 to March 2013 were reviewed, and 815 non-gallblader cancer patients（excluding the population and diseases that had obvious relevance to the studied varibles） admitted during the same period served as control. Using a case-control design, the relevant risk factors for gallbladder cancer were analyzed.Results： After independent variable assessment by univariate analysis, multivariate Logistic regression was conducted and the results demonstrated that age（50–70）, occupat ion（far mer）, body mass index（≥27）, gestational number（≥3）, age of menopause（〉50）, blood type（type A）, histor y ofcholecystolithiasis and chronic cholecystitis were the independent risk factors for the occurrence of gallbladder cancer（all P〈0.05）.Conclusion： The above factors may provide reference for the specific case in clinical practice, and facilitate early detection and therapy of gallbladder cancer.
出处
《中国普通外科杂志》
CAS
CSCD
北大核心
2015年第2期190-194,共5页
China Journal of General Surgery
基金
陕西省科学技术厅科技攻关项目资助(2014K11-03-03-12)
陕西省科学技术厅国际合作科技攻关资助项目(2414KW23-01)
关键词
胆囊肿瘤/预防与控制
危险因素
病例对照研究
Gallbladder Neoplasms/Prevention ＆ Control
Risk Factors
Case-Control Studies
