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多肽合成研究进展 被引量：11

Research Progress of Peptide Synthesis
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摘要 多肽是一类生物活性很高的物质。本文从化学合成和生物合成两个方面综述了多肽的合成,介绍了固相合成、液相分段合成法、施陶丁格连接、天然化学连接、光敏感辅助基连接、可去除辅助基连接、化学区域选择连接、氨基酸的羧内酸酐(NCA)法、组合化学法、酶解法、基因工程法、发酵法等合成方法的原理及其优缺点,对多肽合成方法的发展及其中药资源领域的应用进行了展望,为相关研究提供参考。 Peptide is a kind of important biological active substance. This article summarized from two aspects of chemical synthesis and biosynthesis of synthetic polypeptides. The principle advantages and disadvantages of solid - phase synthesis, liquid segment synthesis, Staudinger ligation, native chemical ligation, enzymatic method, genetic engineering and fermentation were introduced. The development of peptide synthesis methods and applications in the field of traditional Chinese medicine resources were prospected.
作者 曲朋 宋利 赵好冬 胡学生 孙佳明 张辉
机构地区 长春中医药大学
出处 《中国现代中药》 CAS 2015年第3期285-289,295,共6页 Modern Chinese Medicine
基金 国家自然基金项目-肽链热振荡理论对动物类中药材炮制机理的研究(81073048)
关键词 多肽 合成 进展 peptide synthesis progress
分类号 R512.62 [医药卫生—内科学]
  • 相关文献

参考文献36

  • 1历保秋.多肽药物研究与开发[M].北京:人民卫生出版社.2011.
  • 2Sistiabudi Rizaldi, Ivanisevic Albena. Patterning of polypeptides ona collagen-terminated tissue surface [ J ]. Journal of Physics and Chemistry C,2007,111 (31) :11676- 11681.
  • 3Sun Jing, Chen Xuesi, Deng Chao, et al. Direct formation of giantvesicles from synthetic polypeptides [ J ]. Langmuir, 2007,23 (16) : 8308-8315.
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  • 5Giovannoni J, Didierjean C, Durand P, et al. Synthesis and strue-ture of symmetrical bicyclic hexapeptides bridged by metathesis reaction [ J ]. Organic Letters, 2004, 6 ( 20 ) : 3449 -3452.
  • 6黄蓓.多肽固相合成研究进展[J].河南化工,2013,30(1):28-30. 被引量：10
  • 7Zhang Y, Kennan A J. Efficient introduction of protectedguanidines in Boc solid phase peptide synthesis [ J ]. Org Lett,2001,3 ( 15 ) : 2341-2344.
  • 8Redman J E, Ghadiri M R. Synthesis of photoactive p- azido-tetrafluorophenylalanine containing peptide by solid- phase Fmoc methodology [ J ]. Org Lett, 2002,4 ( 25 ) : 4467-4469.
  • 9Stigers K D, Koutroulis M R, Chung D M, et al. Fmoc: a more soluble analogue of 9-fluoenylmethoxycarbonyl protecting group [ J ]. J Org Chem, 2000, 65 (12) : 3858-3860.
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二级参考文献74

  • 1[1]Altreuter D H, Dordick J S, Clark D S. Solid-phase peptide synthesis by ion-paired alpha-chymotrypsin in nonaqueous media[J]. Biotechnol Bioeng, 2003, 81(7):809-817.
  • 2[2]Wang G, Mahesh U, Chen G Y, et al. Solid-phase synthesis of peptide vinyl sulfones as potential inhibitors and activity-based probes of cysteine proteases[J]. Org Lett, 2003, 5(5):737-740.
  • 3[3]Krishna Kumar M, Rajasekharan Pillai V N, Mathew B. An efficient gel-phase synthesis of peptides on a high capacity flexible crosslinked polystyrene support:comparison with Merrifield resin[J]. J Pept Sci, 2002, 8(5):183-191.
  • 4[4]Boas U, Brask J, Christensen J B, et al. The ortho backbone amide linker (o-BAL) is an easily prepared and highly acid-labile handle for solid-phase synthesis[J]. J Comb Chem, 2002, 4(3):223-228.
  • 5[5]Gu W, Silverman R B. New stable backbone linker resins for solid-phase peptide synthesis[J]. Org Lett, 2003, 5(4):415-418.
  • 6[6]Melnyk O, Fruchart J S, Grandjean C, et al. Tartric acid-based linker for the solid-phase synthesis of C-terminal peptide alpha-oxo aldehydes[J]. J Org Chem, 2001, 66(12):4153-4160.
  • 7[7]Bui C T, Ercole F, Pham Y, et al. Improving the performance of an acid-labile 4-hydroxymethyl phenoxyacetic acid (HMP) linker on resin and SynPhase grafted solid-supports[J]. J Pept Sci, 2000, 6(10):534-538.
  • 8[8]Yan L Z, Mayer J P. Use of trichloroacetimidate linker in solid-phase peptide synthesis[J]. J Org Chem, 2003, 68(3):1161-1162.
  • 9[9]Redman J E, Ghadiri M R. Synthesis of photoactive p-azidotetrafluorophenylalanine containing peptide by solid-phase Fmoc methodology[J]. Org Lett, 2002, 4(25):4467-4469.
  • 10[10]Zhang Y, Kennan A J. Efficient introduction of protected guanidines in Boc solid phase peptide synthesis[J]. Org Lett, 2001, 3(15):2341-2344.

共引文献41

同被引文献113

引证文献11

二级引证文献68

中国现代中药
2015年 第3期

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