摘要
目的研究尿路感染病原菌的分布及其耐药性,为临床使用抗菌药物提供依据。方法收集2011年1月至2014年6月尿培养阳性菌株,应用M icro Scan Walk Aw ay40细菌鉴定及药敏分析系统对分离菌进行鉴定及药敏测定,根据CLSI 2014版标准判断药敏结果,用WHONET 5.6软件进行数据分析。结果共分离出2 028株病原菌,革兰阴性杆菌占65.3%,革兰阳性球菌占22.1%,真菌占12.6%。革兰阴性杆菌对亚胺培南、美洛培南、哌拉西林/他唑巴坦、头孢哌酮/舒巴坦较敏感。屎肠球菌对所测试抗菌药物耐药率显著高于其他肠球菌,未发现耐万古霉素、利奈唑胺的革兰阳性球菌。结论尿路感染病原菌分布广泛,仍以革兰阴性杆菌为主,细菌耐药谱有较大差异,建议临床医生根据病原学监测资料有针对性地选择抗菌药物。
Objective To investigate the distribution and drug resistance of pathogenic bacteria causing urinary tract infection,in order to further provide the reference for rational use of antibacterial agents.Methods The strains isolated from the urine in our hospital from January 2011 to June 2014 were collected,the identification and antimicrobial susceptibility were performed by MicroScan WalkAway40.Drug resistance was judged according to CLSI 2014 and WHONET 5.6 software was used to analyze the data.Results A total of 2 028 bacterial strains were isolated.Gramnegative bacilli,Gram-positive cocci and Fungus accounted for 65.3%22.1%and 12.6%,respectively.The susceptible rate of Gran-negative bacilli was higher to imipenem,meropenem,piperacillin/tazobactam,cefoperazone/sulbactarn.The resistance rate of E.faecium to most of the drugs tested was significantly higher than other enterococci.No Gram-positive cocci was resistant to vancomycin or linezolid.Conclusion Urinary tract infection pathogens are widely distributed.The main pathogen is still Gram-negative bacilli and bacterial resistance patterns are quite different.Doctors should select the antibiotics based on the etiology of monitoring data.
出处
《实用药物与临床》
CAS
2015年第3期326-329,共4页
Practical Pharmacy and Clinical Remedies
关键词
尿路感染
病原菌
耐药性
抗菌药物
Urinary tract infection
Pathogenic bacteria
Drug resistance
Antibacterial agents
