摘要
目的:探讨相较于正常人,风湿性心脏病(RHD)患者的血液细胞因子及CD4+CD25+调节性T细胞的改变及意义。方法:分析2012年4月至2013年7月在我院接受住院治疗的RHD患者(观察组)的临床资料,对照组是从我院体检中心选取的健康体检人员,对两组研究对象外周血标本中的转化生长因子-β1(TGF-β1)、肿瘤坏死因子-α(TNF-α)、白细胞介素10(IL-10)、白细胞介素6(IL-6)及CD4+CD25+调节性T细胞表达水平进行检测和比较。结果:本研究共纳入受试者76例,其中观察组患者40例,对照组36例。观察组患者的CD4+CD25+T占淋巴细胞比例(t=17.37,P<0.01)、CD4+CD25+Foxp3+Treg占CD4+T比例(t=9.224,P<0.01)均显著低于对照组;观察组患者的TGF-β1(t=9.036,P<0.01)、IL-10(t=12.11,P<0.01)均显著低于对照组,而TNF-α(t=2.331,P=0.013)、IL-6(t=2.239,P<0.01)水平则高于对照组,差异均有统计学意义。结论:RHD患者CD4+CD25+调节性T细胞水平明显降低,血液细胞因子如TGF-β1和IL-10也相应地出现下降。
Objective：To discuss the changes and significance of CD4＋ CD25＋ regulatory T cells and cytokines in patients with rheumatic heart disease compared to the normal people. Methods： Clinical data of patients with RHD received treatment at our hospital from April 2012 to July 2010 was retrospectively analyzed. The normal control group was the healthy physical examination persons form the medical examination center at our hospital. The expression levels of growth factor 13 1 （ TGF-131 ） ,tumor necrosis factor alpha （ TNF- or） ,interleukin-10 （IL-10） ,interleukin-6 （IL-6） and CD4＋CD25＋regnlatory T cells in the peripheral blood samples of the objects in the two groups were detected and compared. Results. A total of 76 patients were retrospective analyzed,including 40 in observe group and 60 in control group. The percent of CD4＋CD25＋T accounted for lymphocyte and the percent of CD4＋CD25＋Foxp3＋Treg accounted for CD4＋T in observe group were obviously lower than those in control group. The TGF-[M and IL-10 in observe group were obviously lower than those in control group. The TNF-ct and IL-6 in observe group were obviously higher than those in control group. The differences had statistical significance. Conclusion： The CIM~ CD25~ regulatory T cells in patients with RHD were obviously decreased. The blood cytokines such as TGF-IM and IL-10 were corresponding declined.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2015年第3期389-392,共4页
Chinese Journal of Immunology
