摘要
目的:总结兰索拉唑(LPZ)联合药物治疗消化系统疾病以及与其他药物间相互作用的现状,为提高LPZ联合用药的安全性和有效性提供文献支撑。方法:对LPZ联合西药治疗消化系统疾病及其相互作用机制研究进行文献检索、分析与归纳。结果:LPZ主要通过抑酸作用治疗多种消化系统疾病,并可通过细胞色素P450、P-糖蛋白等多种机制影响联合用药药物的生物利用度。结论:今后需着重研究LPZ联合用药的作用机制、药效学评价和个体化用药差异,以确保联合用药的安全性和科学性。
Objective： Summary of lansoprazole combined with drugs in the treatment of digestive system diseases and drug interactions,and thinking on the related issues,in order to provide literature support for improving the safety and efficacy of lansoprazole combined drugs. Methods： This paper retrievalled,analysed and induced the studies of lansoprazole combined with western medicine in the treatment of digestive system diseases,and the interaction mechanism of lansoprazole combined with drugs. Results： Lansoprazole was used to treat digestive system diseases mainly through its acid suppression effect,and through various mechanisms,such as cytochrome P450,P-glycoprotein,to effect the drug bioavailability of drug combination. Conclusion： In the future,we should focus on the mechanism of LPZ combination,pharmacodynamics evaluation and individualized therapy,in order to ensure drug combination safety and science.
出处
《中国药物评价》
2015年第1期21-23,30,共4页
Chinese Journal of Drug Evaluation
