摘要
Hepatitis C virus(HCV) is a potent human pathogen and is one of the main causes of chronic hepatitis round the world. The present review describes the evidencebased consensus on the diagnosis, prevention and management of HCV disease. Various techniques, for the detection of anti-HCV immunoglobulin G immunoassays, detection of HCV RNA by identifying virus-specific molecules nucleic acid testings, recognition of core antigen for diagnosis of HCV, quantitative antigenassay, have been used to detect HCV RNA and core antigen. Advanced technologies such as nanoparticlebased diagnostic assays, loop-mediated isothermal amplification and aptamers and Ortho trak-C assay have also come to the front that provides best detection results with greater ease and specificity for detection of HCV. It is of immense importance to prevent this infection especially among the sexual partners, injecting drug users, mother-to-infant transmission of HCV, household contact, healthcare workers and people who get tattoos and piercing on their skin. Management of this infection is intended to eradicate it out of the body of patients. Management includes examining the treatment(efficacy and protection), assessment of hepatic condition before commencing therapy, controlling the parameters upon which dual and triple therapies work, monitoring the body after treatment and adjusting the co-factors. Examining the treatment in some special groups of people(HIV/HCV co-infected, hemodialysis patients, renal transplanted patients).
Hepatitis C virus （HCV） is a potent human pathogenand is one of the main causes of chronic hepatitis roundthe world. The present review describes the evidencebasedconsensus on the diagnosis, prevention andmanagement of HCV disease. Various techniques, for thedetection of anti-HCV immunoglobulin G immunoassays,detection of HCV RNA by identifying virus-specificmolecules nucleic acid testings, recognition of coreantigen for diagnosis of HCV, quantitative antigenassay, have been used to detect HCV RNA and coreantigen. Advanced technologies such as nanoparticlebaseddiagnostic assays, loop-mediated isothermalamplification and aptamers and Ortho trak-C assayhave also come to the front that provides best detectionresults with greater ease and specificity for detectionof HCV. It is of immense importance to prevent thisinfection especially among the sexual partners, injectingdrug users, mother-to-infant transmission of HCV,household contact, healthcare workers and people whoget tattoos and piercing on their skin. Management of thisinfection is intended to eradicate it out of the body ofpatients. Management includes examining the treatment（efficacy and protection）, assessment of hepatic conditionbefore commencing therapy, controlling theparameters upon which dual and triple therapies work,monitoring the body after treatment and adjusting theco-factors. Examining the treatment in some specialgroups of people （HIV/HCV co-infected, hemodialysispatients, renal transplanted patients）.
