摘要
目的检测宫颈癌组织中血管内皮生长因子（VEGF）及细胞分化抑制因子（Id）-1的表达情况，分析其在宫颈癌组织中的表达与临床病理参数之间的关系。方法采用免疫组化法检测VEGF及Id-1在60例宫颈癌组织及30例正常宫颈组织中的表达水平。结果宫颈癌组织中VEGF在癌组织中阳性率80．00％（48／60），明显高于正常宫颈组织的6．67％（2／30）（X2=43．56，P〈0．01）；宫颈癌癌组织中Id-1阳性率73．34％（44／60），明显高于正常宫颈组织的10．00％（3／30）（X2=38．31，P〈0．01）；宫颈癌组织中VEGF及Id-1的表达与癌组织的分化程度、FIGO分期及脉管瘤栓密切相关（均P〈0．05）；而与患者年龄、肿瘤大小、病理类型、淋巴结转移无相关性（均P〉0．05）；且两者在宫颈癌组织中表达存在明显的正相关性（r=0．642，P=0．000）。多因素预后回归分析显示：VEGF、Id-1、分化程度、脉管浸润、FIGO分期是宫颈癌患者预后的独立危险因素。结论VEGF及Id-1表达异常与宫颈癌的发生和发展密切相关，两者呈正相关性，联合检测宫颈癌组织中两者的表达可作为临床早期诊断、监测转移及预后情况的依据。
Objective To investigate the expression VEGF and Id - 1 and its possible relationship with the clinical pathological features of cervical cancer. Methods The expression of VEGF and Id - 1 were examined in cer- vical cancer and normal tissues by immunohistochemical SP technique. Results The positive expression rate of VEGF in cervical cancer was 80.00% （48/60） ,which was significantly higher than that in normal tissues 6.67% （2/ 30） （P 〈0.01 ） ;The positive expression rate of Id - 1 protein in cervical cancer was 73.34% （44/60） ,which was significantly higher than that in normal tissues 10.00% （3/30） （ P 〈 0.01 ） ; The expressions of VEGF and Id - 1 were positively correlated with the degree of differentiation, vascular invasion, and FIGO stage （ P 〈 0.05 ）, and while was not significantly associated with age, tumor size,lymph node metastasis, and pathologic types. Expression of VEGF was positively related with expression of Id - 1 in cervical cancer tissues（ r = 0. 642 ,P = 0. 000）. Multiple regression anal- ysis showed that： VEGF, Id - 1, differentiation, vascular invasion, and FIGO were independent prognosis factors for cervical cancer. Conclusion The expressions of VEGF and Id - 1 are correlated with the development of cervical cancer. Detection of the expression of VEGF and Id - 1 in cervical cancer can predict the metastasis and prognosis, which can provide the basis for clinical targeted therapy.
出处
《中国基层医药》
CAS
2015年第5期696-699,共4页
Chinese Journal of Primary Medicine and Pharmacy
关键词
宫颈癌
血管内皮生长因子类
细胞分化抑制因子
Colorectal adenocarcinoma
Vascular endothelial growth factors
Cell differentiation inhibitory factors
