摘要
目的检测谷氨酰氨基转移酶（GGT）、a-L-岩藻糖苷酶（AFU）、异常凝血酶原（DCP）以及甲胎蛋白（AFP）在肝癌患者血清中的含量，探讨其联合检测对原发性肝癌（PHC）诊断的价值。方法GGT、AFU采用速率法，AFP用酶联免疫法，DCP采用放射免疫法，四项指标同步检测。分别检测原发性肝癌组47例、转移性肝癌组35例与健康对照组56例血清标本中GGT、AFU、DCP及AFP含量，结果进行统计学分析。结果PHC组和转移性肝癌组患者GGT、AFU、DCP以及AFP阳性率分别为89．4％、83．0％、74．5％、76．6％和82．9％、48．6％、68．6％、62．9％，与健康对照组阳性率比较，差异均有统计学意义（X2GGT=11．05，x2AFU=7．35，X2DcP=8．34，X2AFP=14．58，均P〈0．01）。AFP与GGT、AFU、DCP联合检测，PHC组和转移性肝癌组的阳性率分别为95．7％，88．6％，与健康对照组阳性率比较，差异有统计学意义（0=10．13，P〈0．05）。结论GGT、AFU、DCP及AFP联合检测可以明显提高肝癌诊断的阳性率和准确性。
Objective To detect the serum levels of a- glutamyltransferase（GGT） ,a - L - fucosidase（AFU）, des - gamma - carbory prothrombin（ DCP）, and alpha fetoprotein（AFP） hepato carcinoma patients, and explore its clini- cal predictive value in the diagnosis of hepatocarcinoma. Methods GGT and AFU was measured by velocity method, radioimmunoassay was used in DCP measurement, and ELISA assay was adopted to measure AFP. The levels of serum GGT, AFU, DCP and AFP were measured in 47 patients with primary hepatic carcinoma,35 patients with secondary liver cancer, and 56 normal people. All results were analyzed by statistic method. Results The positive rates of serum GGT, AFU, DCP and AFP in primary hepatic carcinoma and secondary liver cancer were 89.4%, 83.0% ,74.5%, 76.6% and 82.9% ,48.6% , 68.6% , 62.9%, respectively, which were higher than those of normal people （ 2 XGGT = 11.05, XAFU = 7.35, XDCP2 = 8.34, XWAFP = 14.58, all P 〈 0.01 ）. Combined detection of the four index, the positive rates were 95.7% and 88.6% , which was higher than that of normal people （ X2 = 10.13, P 〈 0.05 ）. Conclusion Com- bined detection the levels of serum GGT, AFU, DCP and AFP can help the early diagnosis of hepatic carcinoma.
出处
《中国基层医药》
CAS
2015年第5期743-745,共3页
Chinese Journal of Primary Medicine and Pharmacy
