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人端粒酶逆转录酶与肿瘤相关性的研究进展

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摘要 1938年,Hermann Muller通过X射线照射果蝇产生突变体,发现了染色体末端的特殊结构并命名为端粒（telomere）。端粒是真核细胞染色体的末端物质。它作为一种保护性的结构单位,在维持染色体稳定性中起着重要的作用。人类的端粒由TTAGGG重复序列构成,长度大约2~15 kb[1]。端粒在染色体末端形成T环,不但可以防止染色体重排和末端融合,而且可以保护编码DNA序列,防止DNA在复制中丢失,起到了维持染色体稳定性的作用。
作者 曹渊 沈慧玲 许文林
机构地区 江苏大学附属人民医院肿瘤科
出处 《蚌埠医学院学报》 CAS 2015年第3期411-413,共3页 Journal of Bengbu Medical College
基金 国家自然科学基金资助项目(81070423 81101677) 江苏省自然科学基金资助项目(BK2010332)
关键词 肿瘤 端粒 端粒酶 人端粒酶逆转录酶 综述
分类号 R730 [医药卫生—肿瘤]
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参考文献32

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二级参考文献30

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蚌埠医学院学报
2015年 第3期

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