摘要
目的调查上海地区体检人群甲状腺功能异常的情况以及在健康体检中的必要性。方法选择6 112名进行健康体检并接受甲状腺功能检测的上海地区人员。受检人员清晨空腹取静脉血,使用西门子ADVIA CENTAUR XP全自动化学发光免疫分析仪检测血清三碘甲状原氨酸(T3)、甲状腺素(T4)、游离三碘甲状原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、甲状腺球蛋白抗体(TGAb)和甲状腺过氧化物酶抗体(TPOAb),对检测结果进行统计学分析。结果在6 112名受检者中,甲状腺功能亢进(甲亢)、甲状腺功能减退(甲减)、亚临床甲亢及亚临床甲减的检出率分别为0.47、0.34、0.62及2.55,甲状腺疾病女性发病率高于男性(P=0.001)。女性受检者血清甲状腺激素或自身抗体异常率也显著高于男性受检者(P=0.001)。10.37%的受检者血清甲状腺激素正常,但甲状腺自身抗体水平升高。随着年龄的增长,甲状腺疾病的发病率和血清甲状腺激素或自身抗体异常率均呈明显增高趋势。结论上海地区甲状腺功能紊乱以甲减和亚临床甲减为主,女性发病率高于男性,且与年龄相关。在健康体检中加入甲状腺功能及相关自身抗体检查是非常必要和有价值的。
Objective To investigate the situation of thyroid dysfunction among physical examination subjects in Shanghai,and analyze the necessity of thyroid function test in healthy physical examination.Methods A total of 6 112 subjects in Shanghai undergoing healthy physical examination,including serum thyroid hormone and thyroid autoantibody determinations,were enrolled.Their fasting venous blood samples were collected at early morning.Serum triiodothyronine（T3）,thyroxin（T4）,free triiodothyonine（FT3）,free thyroxin（FT4）,thyroid stimulating hormone（TSH）,antithyroglobulin antibody（TGAb） and thyroid peroxidase antibody（TPOAb） were detected by SIEMENS ADVIA CENTAUR XP automatic chemiluminescence analyzer.The results were analyzed statistically.Results Among the 6 112 subjects,the detection rates of hyperthyroidism,hypothyroidism,subclinical hyperthyroidism and subclinical hypothyroidism were0.47,0.34,0.62 and 2.55,respectively.Female incidence rates of hyperthyroidism,hypothyroidism,subclinical hyerthyroidism and subclinical hypothyroidism were higher than those in males（P = 0.001）.Female abnormal rates of serum thyroid hormone and thyroid autoantibodies were significantly higher than those in males（P = 0.001）.Serum thyroid hormone in 10.37% of the subjects was normal,however,with the increasing levels of thyroid autoantibodies.With the increasing of age,the incidence rate of thyroid dysfunction and the abnormal rates of serum thyroid hormone and thyroid autoantibodies showed a trend of increase.Conclusions Hypothyroidism and subclinical hypothyroidism are major thyroid dysfunctions in Shanghai,with higher female incidence and abnormal rates than male＇s,and there is a relationship with age.The determinations of thyroid hormone and thyroid autoantibodies in healthy physical examination are very necessary and valuable.
出处
《检验医学》
CAS
2015年第3期219-223,共5页
Laboratory Medicine
基金
国家高技术研究发展计划资助项目(2007AA02Z409)
关键词
甲状腺激素
甲状腺自身抗体
健康体检
Thyroid hormone
Thyroid autoantibody
Healthy physical examination
