摘要
目的:观察消积颗粒对慢性盆腔炎患者的治疗效果及其对患者免疫功能的影响。方法:选取我院收治的慢性盆腔炎患者100例,随机分为观察组与对照组,各50例,观察组患者给予消积颗粒口服治疗,对照组给予甲硝唑片联合左氧氟沙星片口服治疗,两组均以治疗4周为1个疗程,连续治疗2个疗程。观察两组患者治疗前后白介素-6(IL-6)、T细胞亚群变化情况,对比两组治疗前后中医证候、视觉模拟疼痛评分(VAS评分)、局部体征评分改善情况及临床疗效。结果:两组治疗后IL-6、CD3+、CD4+、CD4+/CD8+显著高于治疗前,CD8+显著低于治疗前(P<0.05),观察组治疗后上述指标改善较对照组更为显著(P<0.05);观察组治疗后中医证侯、VAS评分、局部体征改善均显著优于对照组(P<0.05);观察组治疗后总有效率显著高于对照组(P<0.05)。结论:消积颗粒可调节慢性盆腔炎患者免疫功能,改善临床症状及局部体征,值得临床推广应用。
Objective： To observe the therapeutic effect of Xiaoji granule on the immunological function of the patients with chronic pelvic inflammatory disease. Methods.. A total of 100 patients with chronic pelvic inflammatory disease admitted in our hospital were enrolled in our study and randomized into the observation group and the control group with 50 cases in each group. The patients in the observation group were orally given Xiaoji granules, while the patients in the control group were given metronidazole and levofloxaein. Four-week treatment was taken as one course, and they were continually treated for two courses. The change of interleukin-6 （I1-6） and T cell subsets before and after treatment in the two groups was observed. The improvement of TCM syndrome score, visual analogue scale （VAS）, and local sign score, and the clinical efficacy before and after treatment in the two groups were compared. Results： The levels of IL-6, CD3＋ , CD4＋ , and CD4＋/CD8＋ after treat- ment in the two groups were significantly higher than those before treatment, while the CD8＋ level was significantly lower than that before treatment （P〈0.05）. The improvement of the above indicators after treatment in the observation group was more significant than that in the control group （P〈0.05）. The improvement of TCM syndrome score, VAS, and local sign score after treatment in the observation group was significantly superior to that in the control group （P〈0.05）. The total effective rate after treatment in the observation was significantly higher than that in the control group （P〈0. 05）. Conclusions： Xiaoii granules can regulate the patients＂ immunological functions, and improve the clinical symptoms and local signs, so that it de- serves to be widely recommended in the clinic.
出处
《海南医学院学报》
CAS
2015年第5期689-691,共3页
Journal of Hainan Medical University
基金
河北省科技支撑项目~~
