摘要
目的探讨Ⅲ期卵巢上皮性癌复发的危险因素。方法将Ⅲ期卵巢上皮性癌患者80例,分为复发组26例,未复发组54例。观察患者的临床病理参数以及治疗等因素。结果复发组在腹水肿瘤细胞学、残留病灶、淋巴结清除、术后2个月CA125水平、化疗疗程、MMP-2表达方面与未复发组比较差异显著(P<0.05);多因素Logistic回归分析显示腹水肿瘤细胞学呈阳性、残留病灶≥2 cm、淋巴结清除、术后2个月CA125≥35 U/L、MMP-2表达阳性是影响复发的独立危险因素。结论Ⅲ期卵巢上皮性癌复发的预测因素有术后CA125、MMP-2水平、残留病灶大小、淋巴结是否清除、腹水肿瘤细胞学性质。
Objective To investigate the risk factors of stageⅢrecurrent ovarian epithelial cancer .Methods 80 stageⅢovarian epithelial cancer patients were divided into the recurrent group （n=26）and the non-recurrent group （n=54）.Clini-cal parameters ,histological parameters , chemotherapy , and other factors were observed .Results There were significant differ-ences in ascites cytology,residual lesions,lymph node dissection,CA125 level 2 months after operation,chemotherapy courses, MMP-2 expression between the 2 groups（P〈0.05）;Multivariate analysis showed that positive expression of ascites cytology ,re-sidual lesions≥2 cm,lymph node dissection,CA125≥35 U/L 2 months after operation,and positive expression of MMP-2 were independent risk factors affecting recurrence in patients with ovarian epithelial cancer .Conclusion The important prognostic fac-tors of stage Ⅲrecurrent ovarian epithelial cancer are CA 125 and MMP-2 level after operation,residual tumor size,lymph node resection status and cytology of ascites tumors .
出处
《实用癌症杂志》
2014年第4期415-417,420,共4页
The Practical Journal of Cancer
关键词
卵巢肿瘤
复发
危险因素
Ovarian neoplasm
Recurrence
Risk factors
