摘要
目的:探讨埃索美拉唑联合黛力新治疗老年伴抑郁非糜烂性胃食管反流病(non-erosive reflux disease,NERD)的疗效及对生活质量的影响.方法:将青海大学附属医院老年科门诊2012-01/2013-12收治的82例伴抑郁老年NERD患者随机分为对照组(n=41)和观察组(n=41),两组均于早餐前给予20 mg埃索美拉唑口服治疗,仅观察组于早餐后口服20 mg黛力新,两组均持续用药8 wk.采用GERD问卷分析两组治疗前后的总体及不同症状得分来评价疗效,分别以治疗前后的汉密尔顿抑郁量表(Hamilton depression scale,HAMD)、Zung抑郁自评量表(self-rating depression scale,SDS)及中文版SF-36生活质量量表评价抑郁及生活质量改善情况,同时分析两组用药期间的不良反应.结果:观察组的总有效率高于对照组(92.7%vs 75.6%,P<0.05);两组治疗前的症状、抑郁及生活质量评分的差异均无统计学意义,但治疗后的以上各指标均优于治疗前(P<0.05);与对照组相比,观察组治疗后的GERD问卷总分及不同症状得分和HAMD、SDS评分均降低,生活质量总分及躯体相关、心理相关生活质量得分均升高(P<0.05).两组治疗期间不良反应较轻,发生率较低且差异无统计学意义(P>0.05).结论:埃索美拉唑联合黛力新治疗老年伴抑郁NERD的效果较好,不仅可改善相关症状,同时可缓解抑郁并提高生活质量,患者可耐目的:探讨埃索美拉唑联合黛力新治疗老年伴抑郁非糜烂性胃食管反流病(non-erosive reflux disease,NERD)的疗效及对生活质量的影响.方法:将青海大学附属医院老年科门诊2012-01/2013-12收治的82例伴抑郁老年N E R D患者随机分为对照组(n=41)和观察组(n=41),两组均于早餐前给予20 mg埃索美拉唑口服治疗,仅观察组于早餐后口服20 m g黛力新,两组均持续用药8 w k.采用GERD问卷分析两组治疗前后的总体及不同症状得分来评价疗效,分别以治疗前后的汉密尔顿抑郁量表(Hamilton depression scale,H A M D)、Z u n g抑郁自评量表(s e l f-r a t i n g depression scale,SDS)及中文版SF-36生活质量量表评价抑郁及生活质量改善情况,同时分析两组用药期间的不良反应.结果:观察组的总有效率高于对照组(92.7%vs 75.6%,P<0.05);两组治疗前的症状、抑郁及生活质量评分的差异均无统计学意义,但治疗后的以上各指标均优于治疗前(P<0.05);与对照组相比,观察组治疗后的GERD问卷总分及不同症状得分和HAMD、S D S评分均降低,生活质量总分及躯体相关、心理相关生活质量得分均升高(P<0.05).两组治疗期间不良反应较轻,发生率较低且差异无统计学意义(P>0.05).结论:埃索美拉唑联合黛力新治疗老年伴抑郁NERD的效果较好,不仅可改善相关症状,同时可缓解抑郁并提高生活质量,患者可耐受,安全有效,可在老年伴抑郁NERD治疗中推广.
AIM：To explore the efficacy of esomeprazole combined with Deanxit in the treatment of non-erosive gastrooesophageal reflux disease（NERD） with depression in elderly patients and their impact on quality of life.METHODS：From January 2012 to December2013,82 elderly NERD outpatients with depression treated at our department were randomly assigned into either a control group or an observation group（n = 41 for each）.Both groups received 20 mg esomeprazole orally before breakfast,and only the observation group received 20 mg Deanxit orally after breakfast for eight consecutive weeks.The gastroesophageal reflux disease（GERD）questionnaire was used to analyze the overall and individual symptom scores before and after treatment.The Hamilton depression scale（HAMD）,Zung self-rating depression scale（SDS） and the Chinese version of SF-36 scale were employed to evaluate the improved status of depression and quality of life.Meanwhile,the adverse reactions during medication were recorded.RESULTS：The total effective rate in the observation group was higher than that in the control group（92.7%vs 75.6%,P 〈 0.05）.No significant difference was observed in symptoms,depression or quality of life before treatment between the two groups,but the above parameters were significantly better after treatment in both groups（P 〈 0.05）.In comparison with the control group,the observation group had significantly decreased scores of overall and individual symptoms of the GERD questionnaire and HAMD and SDS scores,but increased scores of body and psychological related quality of life（P 〈 0.05）.Adverse reactions were mild,and similar between the two groups（P 〉 0.05）.CONCLUSION：Esomeprazole combined with Deanxit has a better effect than esomeprazole alone in the treatment of elderly NERD with depression in terms of improved symptoms,quality of life and depression.
出处
《世界华人消化杂志》
CAS
2015年第5期777-781,共5页
World Chinese Journal of Digestology
关键词
埃索美拉唑
黛力新
老年
伴抑郁非糜烂性胃食管反流病
疗效
Esomeprazole
Deanxit
Elderly
Nonerosive gastroesophageal reflux disease with depression
Effect
