摘要
目的：观察使用贝那普利治疗老年高血压早期肾损害的临床疗效情况。方法选取2011年1月～2013年1月收治的高血压早期肾损害老年患者400例，随机分为观察组与对照组，对照组使用拉西地平进行治疗，观察组联合使用贝那普利进行治疗，观察两组患者临床疗效。结果观察组治疗效果明显优于对照组（显效率、总有效率较高，P＜0.05）；治疗后尿微量白蛋白、血肌酐、尿素氮及胱抑素C等指标水平明显低于对照组，差异有统计学意义（P＜0.05）。结论使用贝那普利治疗老年高血压早期肾损害具有理想的临床疗效，尤其与拉西地平等进行联合治疗，能够有效的降低肾损害临床指标水平，改善患者临床症状，可进一步在临床上进行推广应用。
Objective To observe the clinical effect of benazepril in the treatment of early renal damage in elderly hypertension. Methods 400 patients with early renal damage in elderly hypertension who were selected in our hospital from January 2011 to January 2013 were randomly divided into control group treated with lacidipine and observation group treated with lacidipine combined benazepril, to comparative observe the clinical effect of the two groups. Results The clinical effect as the effective rate and the total effective rate were higher in observation group than control group （P 〈 0.05）, the urinary album, the serum creatinine, the urea nitrogen and the cystatin C and other index levels were lower after operation in observation group than control group（P〈0.05）, the differences was statically significant. Conclusion Benazepril in the treatment of early renal damage in elderly hypertension has ideal clinical effect, could effectively decrease the index levels of renal damage and improve the clinical symptoms of patients especially combined with lacidipine, could be further of clinical application and popularization.
出处
《中国医药科学》
2015年第3期114-116,共3页
China Medicine And Pharmacy
关键词
老年高血压
早期肾损害
贝那普利
Elderly hypertension
Early renal damage
Benazepril
