摘要
目的：探讨纵膈胃肠道外间质瘤的临床病理学特征和鉴别诊断。方法对1例后纵膈胃肠道外间质瘤进行临床组织病理学和免疫组化观察，并复习相关文献。结果镜下见肿瘤细胞弥漫分布，以梭形细胞为主，无异型性，核分裂相（1~2个/50HPF）。免疫组化：梭形细胞CD117（＋）、CD34（＋）、vimentin（＋）、CD68（-）、S-100（-）、desmin（-）、SMA（-）。结论胃肠道外间质瘤是一种特殊类型的梭形细胞肿瘤，罕见于纵膈，其生物学行为高于胃肠道间质瘤，预后比胃肠道间质瘤差。我们查阅了大量文献，未见报道过，其应注意与平滑肌瘤、神经纤维瘤鉴别。
Objective To evaluate the clinicopathological features of 1 patient with the extra gastrointestinal stromal tumor（EGIST）. Methods A retrospective study was performed to analyze the histopathologic features in 1 case of GIST behind mediastinum. Immunohistochemical staining for CD117, CD34, Vimentin, CD68, S-100, Desmin and SMA was performed. And literatures was reviewed. Results In this case of GIST behind mediastinum, the tumor cells diffuse distribution, spindle cells was dominant, here was 1-2 mitotic per 50 HPF under the microscope;Immunohistochemistry performance of CD117, CD34 and Vimentin was strong expression.CD68,S-100, Desmin and SMA staining was negative. Conclusion Stromal tumor of parenteral is the special type of spindle cell tumors. It is rare in the mediastinum.Its biological behavior is similar to stromal tumors of gastrointestinal. We reviewed a lot of literatures,it has not been reported until now. It must be Identificated with smooth muscle tumors and neurofibromas.
出处
《中国医药科学》
2015年第3期153-154,180,共3页
China Medicine And Pharmacy
关键词
胃肠道外间质瘤
纵膈
临床病理
Extra-gastrointestinal
Behind mediastinum
Clinical pathology
