期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Wnt信号通路对牙齿发育和牙囊成骨向分化的调控作用 被引量：2

The role of Wnt signalling pathways in tooth development and the osteogenic differentiation of dental follicle
下载PDF
导出
摘要 Wnt信号通路包括经典Wnt/β-catenin信号通路和非经典通路,对个体组织发育和干细胞的自我更新具有重要调控作用,在包括颅面部器官在内的几乎所有器官发生过程中都必需Wnt信号通路的调控。研究发现,Wnt/β-catenin信号通路不仅在牙齿发育过程中参与了上皮和间充质的相互作用,在牙囊细胞的分化过程亦有Wnt信号通路的参与。本文就Wnt信号通路在牙齿发育和牙囊成骨/成牙骨质向分化中的调控作用研究进展作一综述。 Wnt signalling pathways include the canonical Wnt pathway and non -canonical pathways.Grow-ing evidence indicates that Wnt signaling pathways orchestrate tissue development and stem cell self-renewal.Wnt/β-catenin signaling is known to be crucial for tooth development and bone formation.Furthermore,several members of the Wnt family were observed in the presumptive dental epithelium or mesenchyme.The differentiation of dental follicle cells needs the regulation of Wnt signaling.This review emphasizes the role of Wnt signalling pathways in tooth devel-opment and the osteogenic differentiation of dental follicle.
作者 陈婵婵 凌均棨
机构地区 中山大学光华口腔医学院.附属口腔医院.口腔医学研究所
出处 《牙体牙髓牙周病学杂志》 CAS 2015年第3期175-178,共4页 Chinese Journal of Conservative Dentistry
基金 国家自然科学基金资助项目(81170932)
关键词 WNT信号通路 牙齿发育 牙囊 成骨向分化 Wnt signalling pathways tooth development dental follicles osteogenic differentiation
分类号 R780.2 [医药卫生—口腔医学]
  • 相关文献

参考文献30

  • 1Maye P, Zheng J, Li L, et al. Muhiple mechanisms for Wntll- mediated repression of the canonical Wnt signaling pathway [ J ]. J Biol Chem, 2004, 279(23) : 24659 -24665.
  • 2van Amerongen R, Nusse R. Towards an integrated view of wnt signaling in development [ J 1. Development, 2009, 136 ( 19 ) : 3205 - 3214.
  • 3Sarkar L, Sharfm PT. Expression of Writ signalling pathway genes during tooth development[ JJ. Mech Dev, 1999, 85 (1 - 2) : 197 -200.
  • 4Wang B, Li H, Liu Y, et al. Expression patterns of WNT/13 - CATENIN signaling molecules during human tooth development [J~. J Mol Histol, 2014, 45(5) :487 -496.
  • 5Ou Y, Ling J, Wei X, et al. Wnt/13-Catenin signaling partici- pates in eementoblast/Osteoblast differentiation of dental follicle zells[J~. Connect Tissue Res, 2012, 53(5) : 390 -397.
  • 6刘燕,杜宇,凌均棨,项露赛.无翅型MMTV整合位点家族成员3在大鼠牙囊及牙囊细胞成骨分化中的表达[J].中华口腔医学杂志,2013,48(7):423-428. 被引量：4
  • 7Xiang L, Chen M, He L. WntSa regulates postnatal dental folli- cle stem/progenitor ceils [ J]. Stem Cell Res, 2014,5 (6) : 135.
  • 8Cai J, Mutoh N, Shin J, et al. WntSa plays a crucial role in de- termining tooth size during murine tooth development [ J ]. Cell Tissue Res, 2011,345(3) : 367 -377.
  • 9Lohi M, Tucker AS, Sharpe PT. Expression of Axin2 indicates a role for canonical Wnt signaling in development of the crown and root during pre-and postnatal tooth development [ J ]. Dev Dyn, 2010, 239(1) :160 -167.
  • 10Lehnen SDM, GStz W, Baxmann M, et al. Immunohistochemi- cal evidence for sclerostin during cementogenesis in mice [ J ]. Ann Anat, 2012, 194(5) : 415 -421.

二级参考文献26

  • 1王浈,刘宏伟,金岩,刘兰宁,刘源,轩昆.人牙囊细胞的分离培养和生物学特性[J].牙体牙髓牙周病学杂志,2004,14(9):490-493. 被引量：13
  • 2Logan CY,Nusse R.The Wnt signaling pathway in development and disease.Annu Rev Cell Dev Biol,2004,20:781-810.
  • 3Barrow JR,Howell WD,Rule M,et al.Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis.Dev Biol,2007,312(1):312-320.
  • 4Kishimoto J,Burgeson RE,Morgan BA.Wnt signaling maintains the hair-inducing activity of the dermal papilla.Genes Dev,2000,14(10):1181-1185.
  • 5Barrow JR,Thomas KR,Boussadia-Zahui O,et al.Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge.Genes Dev,2003,17(3):394-409.
  • 6Lewis SL,Khoo PL,De Young RA,etal.Dkkl and Wnt3 interact to control head morphogenesis in the mouse.Development,2008,135(10):1791-1801.
  • 7Niemann S,Zhao C,Pascu F,et al.Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family.Am J Hum Genet,2004,74(3):558-563.
  • 8Warotayanont R,Frenkel B,Snead ML,et al.Leucine-rich amelogenin peptide induces osteogenesis by activation of the Wnt pathway.Biochem Biophys Res Commun,2009,387 (3):558-563.
  • 9Liu D,Yao S,Pan F.et al.Chronology and regulation of gene expression of RANKL in the rat dental follicle.Eur J Oral Sci,2005,113(5):404-409.
  • 10Que BG,Wise GE.Colony-stimulating factor-1 and monocyte chemotactic protein-1 chemotaxis for monocytes in the rat dental follicle.Arch Oral Biol,1997,42(12):855-860.

共引文献3

同被引文献23

引证文献2

二级引证文献4

牙体牙髓牙周病学杂志
2015年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部