摘要
目的通过对血清谷氨酸脱羧酶抗体(GADA)、胰岛细胞抗体(ICA)和胰岛素自身抗体(IAA)3种胰岛自身抗体联合检测,探讨2型糖尿病(T2DM)患者中筛查成人隐匿性自身免疫糖尿病(LADA)的临床意义。方法测定200例诊断T2DM患者GADA、ICA、IAA、BMI、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、空腹C肽、餐后2hC肽、糖化血红蛋白(HbA1c)。检测出其中的LADA患者,并与T2DM患者比较临床指标的差异。结果 200例T2DM患者中共确诊为LADA患者15例(7.5%);与自身抗体阴性组相比,自身抗体阳性组BMI、TC、空腹C肽、餐后2hC肽明显降低,而HbA1c明显增高,差异有统计学意义(P<0.05)。结论 GADA、ICA、IAA联合检测对筛查LADA有重要指导价值,各项临床指标联合胰岛自身抗体检测可提高LADA患者的检出率。
Objective To explore the clinical significance of combined test of glutamic acid decarboxylase antibody（GADA）、islet cell antibody（ICA）and insulin autoantibody（IAA）in screening latent autoimmune diabetes in adults（LADA）from type 2diabetes（T2DM）.Methods In 200T2 DM patients,GADA,ICA,IAA,BMI,HbA1 c,TC,TG,LDL-C,HDL-C,fasting C-peptide and C-peptide of 2-hours post-meal were tested to find out the patients with LADA,whose various indexes were compared with the patients of T2 DM.Results In 200 cases of T2 DM,15cases were detected LADA（7.5%）,compared with islet autoantibodies negative patients,BMI、TC、fasting C-peptide and C-peptide of 2-hours post-meal were lower,but HbA1 cwas higher.There were statistical differences in two group（P〈0.05）.Conclusion The combined test of GADA,ICA,IAA has important guiding value.The combination of clinical indexes and islet autoantibodies can increase detection rate of LADA.
出处
《中国冶金工业医学杂志》
2015年第2期125-127,共3页
Chinese Medical Journal of Metallurgical industry
