摘要
目的:观察芪甲利肺胶囊治疗慢性阻塞性肺疾病(COPD)合并肺结核病的疗效。方法:将2012年1月-2014年9月我院收治的COPD合并肺结核病患者190例按随机数字表法分为观察组101例与对照组89例。对照组接受常规氨茶碱解痉平喘加抗结核治疗,观察组在对照组基础上联合芪甲利肺胶囊辅助治疗,每次3粒,每天3次。2周后观察患者临床症状消失情况;2月后观察痰涂片阴转、病灶吸收、空洞闭合及细胞因子变化情况。结果:治疗2周时,观察组发热、咯血、气喘、咳嗽咳痰等症状的消失率(46.1%)高于对照组(31.7%),差异具有统计学意义(P<0.05)。治疗2个月时,观察组痰涂片阴转率(64.0%)、病灶吸收有效率(91.9%)均高于对照组(分别为48.5%、64.3%),差异具有统计学意义(P<0.05)。两组患者治疗后肿瘤坏死因子-α、干扰素(IFN)-γ水平均出现下降,且观察组IFN-γ下降得更快,两组比较差异有统计学意义(P<0.05)。结论:芪甲利肺胶囊辅助治疗COPD合并肺结核病具有较好的疗效。
OBJECTIVE：To analyze the clinical effects of Qijia lifei capsule on chronic obstructive pulmonary disease（COPD）with tuberculosis（TB）. METHODS：In total of 190 COPD patients with TB of our hospital from Jan. 2012 to Sep. 2014 were divided into experimental group（101 cases）and control group（89 cases）by random number table. Patients in control group were treated with aminophylline of anti-spasmodic and anti-TB,while the patients in experimental group were treated with aminophylline of anti-spasmodic and anti-TB plus Qijia lifei capsule 3 particles/time,3 times/d. The disappearance of clinical symptoms was observed after 2 weeks and sputum smear negative conversion,lesions absorption,void closure and cell factors changes were observed after 2 months. RESULTS：The disappearance rate of symptoms of fever,hemoptysis,asthma,cough and expectoration in experimental group（46.1%） was higher than those of control group（31.7%）（P〈0.05） after 2 week treatment. After two months of treatment,sputum smear negative conversion rate（64.0%）and lesions absorption efficiency（91.9%）in experimental group were higher than those of control group（48.5% and 64.3%）（P〈0.05）. The levels of TNF-α and IFN-γ were decreased in 2groups,and IFN-γ in experimental group was faster. There was significant difference（P〈0.05）. CONCLUSIONS：Adjuvant treatment with Qijia lifei capsule is an effective treatment for COPD patients with TB.
出处
《中国药房》
CAS
北大核心
2015年第11期1541-1543,共3页
China Pharmacy
关键词
芪甲利肺胶囊
慢性阻塞性肺疾病
肺结核病
临床疗效
Qijia lifei capsule Chronic obstructive pulmonary disease Tuberculosis Clinical efficacy
