摘要
目的通过分析腹膜透析(PD)患者红细胞分布宽度(RDW)及其相关影响因素,探讨RDW对PD患者病情评估的应用价值。方法收集144例维持PD患者的RDW、脑钠肽(BNP)、血红蛋白(HB)、血清白蛋白(ALB)、每周重组人促红细胞生成素(r Hu EPO)用量、红细胞平均血红蛋白量(MCH)、高敏C反应蛋白(hs-CRP)、血肌酐、年龄等资料,分析RDW与各临床及实验室检查指标之间的相关关系。结果整组RDW水平超过检测参考值上限占15.28%。不同性别间及是否存在感染组间比较差异无统计学意义。Pearson相关分析提示PD患者的RDW与年龄(r=0.258,P=0.002)、BNP(r=0.212,P=0.011)、hs-CRP(r=0.199,P=0.023)呈正相关;与ALB(r=-0.220,P=0.008)、r Hu EPO/HB(r=-0.173,P=0.038)、MCH(r=-0.469,P<0.001)呈负相关;与总出量、平均动脉压、HB、铁蛋白、血清铁、转铁蛋白饱和度、总铁结合力间无相关性。多元线性逐步回归模型结果提示BNP、年龄、MCH为RDW的相关变量。结论部分腹膜透析患者存在RDW异常,RDW与多种临床指标有关,但其对腹膜透析人群的临床应用价值需要进一步研究。
Objective To investigate the status of the red blood cell distribution width （ RDW） and its related fac-tors in peritoneal dialysis （ PD） patients,and to explore the application value in disease assessment of PD patients. Methods 144 hospitalized PD patients were retrospectively reviewed. The clinical characteristics and parameters such as RDW, brain natriuretic peptide （ BNP） ,hemoglobin （ HB） ,serum albumin （ ALB） , the does of weekly re-combinant human erythropoietin （ rHuEPO ） , mean corpuscular hemoglobin （ MCH ） , high sensitivity C-reactive protein （hs-CRP）, serum creatinine,age were collected to analyze their correlations with RDW. Results The whole level of RDW exceeded the maximum limit detection reference, which accounted for 15. 28%. There was no statistical significance between different gender and the presence of infection group. Pearson correlation analysis showed that RDW was positively correlated with age （ r=0. 258 , P=0. 002 ） , BNP （ r=0. 212 , P=0. 011 ） , hs-CRP （r=0. 199, P=0. 023）,and negatively correlated with ALB（r= -0. 220,P=0. 008）, rHuEPO/HB ratio（r= -0. 173, P=0. 038）, MCH （r= -0. 469,P 〈0. 01）. RDW was not statistically significant with the total out-put, mean arterial pressure, HB, ferroprotein, serum ferrium, transferrin saturation, total iron binding capacity. Multivariate linear regression method showed that RDW was associated with BNP, age, MCH. Conclusion Part of peritoneal dialysis patients get abnormal RDW, which is related to many parameters. Further studies are needed to estimate the application values of RDW in PD patients.
出处
《安徽医科大学学报》
CAS
北大核心
2015年第3期333-336,共4页
Acta Universitatis Medicinalis Anhui
基金
安徽省自然科学基金项目(编号:1408085MH183)
关键词
腹膜透析
尿毒症
红细胞分布宽度
因素分析
peritoneal dialysis
uremia
red blood cell distribution width
factor analysis
