摘要
目的：分析抗甲状腺过氧化酶抗体与早期自然流产的相关性。方法：选取2013年9月～2014年12月到我院就诊的122例早期自然流产患者为病例组，以同期来我院行健康体检的60例健康女性为参照组。采用电化学发光法监测所有对象的血清甲状腺功能，包括抗甲状腺过氧化酶抗体（TPO-Ab）和抗甲状腺球蛋白抗体（TG-Ab），分析比较两组研究对象的监测结果。结果：①病例组的TG-Ab、TPO-Ab水平均明显高于参照组（P＜0.05）；②病例组的TG-Ab阳性率（75.41％）、TPO-Ab阳性率（52.46％）、TA阳性率（50.00％）均显著高于参照组（分别为1.67％、0和1.67％）（P＜0.05）；③多元回归分析结果显示，早期自然流产与抗甲状腺过氧化酶抗体（TPO-Ab）阳性存在相关性。结论：抗甲状腺过氧化酶抗体（TPO-Ab）阳性与早期自然流产存在相关性，需做好甲状腺自身抗体检测和其他措施，降低早期自然流产的发生率。
Objective：To analyze of thyroid peroxidase antibodies and the correlation of early abortion. Selection.Methods：In September 2013 to December 2014 in our hospital 122 cases of patients with early abortion as the case group, with the same period in our line of health check-up of 60 cases of healthy women as control group. Using the electrochemical luminescence method monitoring serum thyroid function of all objects, including resistance to thyroid peroxidase（TPO-Ab）antibodies and anti thyroglobulin antibody（TG-Ab）, analysis and comparison of both groups monitoring results.Results： ①Cases of TG-Ab,TPO-Ab level were significantly higher than that of control group（P〈0.05）;②Cases of TG-Ab positive rate（75.41%）, TPO-Ab positive rate（52.46%）, TA positive rate（50.00%）were significantly higher than that of control group （1.67%, 0 and 1.67% respectively）（P〈0.05）; ③Multivariate regression analysis results show that the early abortion and resistance to thyroid peroxidase （TPO-Ab） antibodies positive correlation. Conclusion anti thyroid peroxidase antibody （TPO-Ab） positive correlation with early abortion, need to make thyroid autoantibodies detection and other measures to reduce the incidence of early abortion.
出处
《北方药学》
2015年第4期150-152,共3页
Journal of North Pharmacy
关键词
自然流产
相关性
抗甲状腺过氧化酶抗体
Spontaneous abortion
Correlation
Resistance to thyroid peroxidase antibodies
