摘要
目的探讨综合防治措施在预防及治疗大剂量阿糖胞苷巩固治疗小儿白血病不良反应中的作用。方法将2012年1月~2014年11月在我院接受以阿糖胞苷为主的综合用药治疗的30例白血病患儿分为A、B两组,A组给予综合防治措施预防和治疗不良反应,B组给予常规治疗,对两组患儿的不良反应发生情况进行对比,分析综合防治措施在不良反应预防及治疗中的作用。结果 A组15例患儿共进行治疗50次,B组15例患儿共进行治疗46次,在巩固治疗中出现的主要不良反应为：药物热、皮疹、神经系统毒性、消化系统毒副作用、骨髓抑制、感染等,其中综合防治组神经系统毒性、消化系统毒副作用、药物热、皮疹及感染等不良反应发生率均明显低于常规治疗组,差异有统计学意义;综合防治组骨髓抑制发生率与常规治疗组无明显差异,但骨髓抑制分级明显低于常规治疗组,差异有统计学意义。结论综合防治措施应用于大剂量阿糖胞苷巩固治疗小儿白血病,能够有效降低治疗过程中皮疹、药物热、神经系统毒性、消化系统毒副作用、感染等不良反应的发生率,降低骨髓抑制的严重程度,保证患儿安全完成综合治疗。
Objective To explore comprehensive prevention and control measures in the high-dose cytarabine consolidation therapy adverse reaction in the treatment of leukemia children. Methods 30 pediatric leukemia patients who integrated treatment from Jan 2012 to Nov 2014 were divided into A group and B group, A group received comprehensive prevention measures for the prevention and treatment of adverse reactions in the treatment, B group received conventional treatment measures. Compared the incidence of adverse reactions of two groups, analysed the effect of comprehensive prevention and control measures in the prevention and treatment of adverse reactions. Results 15 patients of A group were treated a total of 50 times, 15 patients of B group were treated a total of 46 times, the main adverse reactions occured in consolidation therapy for drug fever, rash, nervous system toxicity, digestive system toxicity side effects, bone marrow suppression. Nervous system toxicity, digestive system toxicity side effects, drug fever, rash and infection and other adverse reactions were significantly lower in combined therapy group than the conventional treatment group, the difference was statistically significant. The incidence of bone marrow suppression of combined therapy group had no significant difference compared with that of conventional therapy group, but the clas- sification of bone marrow suppression was significantly lower than that of the conventional treatment group, the difference was statistically significant. Conclusion Application of comprehensive prevention and control measures in the high-dose cytarabine consolidation therapy in children with leukemia, can effectively reduce the incidence rate of rash, drug fever, nervous system, digestive system toxicity side effects and infection, and reduce the severity of bone marrow suppression, ensure the security of comprehensive treatment for children with leukemia.
出处
《中国现代医药杂志》
2015年第2期41-44,共4页
Modern Medicine Journal of China
关键词
综合防治措施
阿糖胞苷
白血病
巩固治疗
不良反应
Comprehensive prevention and control measures Cytarabine Leukemia Consolidation therapy Adverse reactions
