摘要
目的:探讨连接粘附分子A(junctional adhesion molecule A,JAM-A)在人肺癌组织中的表达及与临床病理特征的关系。方法:采用免疫组化SP法检测65例肺癌组织和52例癌旁组织JAM-A的表达,分析其与临床病理特征之间的关系。结果:JAM-A在65例肺癌组织中的表达率为56.9%,明显高于癌旁组织21.2%(P<0.05)。与患者淋巴结转移及TNM分期相关,而与年龄、组织学类型、肿瘤分化程度无关(P>0.05)。结论:JAM-A在非小细胞肺癌中高表达,提示其可能发挥癌基因的功能。
Objective:To study the expression and its significance of Junctional Adhesion Molecule A(JAM-A)related to pathological features in lung cancer patients. Methods:JAM- A expression of cancer tissue was detected by immunohistochemistry SP in 65 patients with lung cancer and compared with pericarcinomatous tissues. Results:The positive expression of JAM- A in lung cancer rate was 56. 9% that was significantly higher than that of noncancerous tissue(11 /52,21. 2%). And it was significantly related to the TNM staging and lymph node metastasis but not related to patient's age,histological type and histologic differentiation. Conclusion:JAM- A highly expressed in non small cell lung cancer which implicated it might play an oncogene role in the lung cancer development.
出处
《现代肿瘤医学》
CAS
2014年第9期2068-2070,共3页
Journal of Modern Oncology
基金
国家自然基金项目(编号:81302055)
关键词
JAM-A
肺癌
免疫组化
JAM-A
lung cancer
immunohistochemistry
