摘要
目的:观察调强放疗同步紫杉醇+顺铂方案化疗治疗食管鳞癌的近期疗效及治疗相关不良反应。方法:我院2010年6月-2013年7月收治的70例初治食管鳞癌患者,分为放化疗组36例和单放组34例。单放组:放疗剂量为DT(60-66)Gy/(30-32)f;放化疗组:放疗开始给予紫杉醇135mg/m2,第1天,顺铂25mg/m2,第1-3天,21天为一个周期,共两个周期。放疗结束后3个月复查食管钡餐片及CT进行疗效评价。结果:放化疗组共36例食管鳞癌患者,治疗结束后3个月总有效率(response rate,RR)=(CP+PR)为91.7%,其中完全缓解率(complete response,CR)为55.6%、部分缓解率(partial response,PR)为36.1%、无缓解率(non-response,NR)为8.3%,总有效率高于单放组(73.5%),且差异有统计学意义(P<0.05)。放化疗组1、2级不良反应发生率高于单放组,有统计学意义(P<0.05),而3级以上不良反应及1、2级放射性肺炎两组无差异(P>0.05)。结论:调强放疗联合紫杉醇+顺铂方案同步化疗治疗食管鳞癌近期疗效好,不良反应患者可耐受。
Objective:To observe the short-term efficacy and adverse reactions of intensity-modulated radio-therapy and concurrent paclitaxel program chemotherapy for esophageal squamous cell carcinoma.Methods:From June 2010 to July 2013,70 previously untreated patients of esophageal squamous cell carcinoma were divided to two groups randomly:36 patients were treated by intensity-modulated radiotherapy and concurrent paclitaxel+cisplatin chemotherapy,and 34 patients treated by intensity-modulated radiotherapy only.Radiotherapy only group:Radiation dose were DT (60-66)Gy/(30-32)f;Chemo-radiotherapy group:Chemotherapy started with the radiotherapy,pa-clitaxel 135mg/m2,d1,cisplatin 25mg/m2,d1 -3,21 days a cycle,for two cycles.To evaluate the effect by esophageal barium meal and CT 3 months after the radiotherapy.Results:In 36 patients of chemo-radiotherapy group,the overall response rate was 91.7%(CR+PR),and complete,partial,non-response rates were 55.6%,36.1%,8.3% re-spectively,the overall response rate was higher than radiotherapy group(73.5%),and the difference has statistical significance(P<0.05).The adverse reactions of grade 1,2 in chemo-radiotherapy group were higher than radiother-apy group(P<0.05),but adverse reactions of grade 3 or more and grade 1,2 of radiation-related pneumonitis were no significant difference between two groups(P>0.05).Conclusion:The short-term efficacy of intensity-modula-ted radiotherapy and concurrent paclitaxel program chemotherapy for esophageal squamous cell carcinoma was better, and the adverse reactions could be tolerated.
出处
《现代肿瘤医学》
CAS
2014年第9期2095-2098,共4页
Journal of Modern Oncology
关键词
食管鳞癌
调强同步化疗
近期疗效
esophageal squamous cell carcinoma
intensity-modulated chemo-radiotherapy
short-term efficacy
