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窄谱中波紫外线对寻常性银屑病患者外周血干扰素诱导的T细胞α趋化因子表达的影响 被引量：7

The effect of the NB-UVB on serum levels of IFN-inducible T cell alpha chemoattractant in psoriasis
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摘要 目的探讨窄谱中波紫外线(NB-UVB)对寻常性银屑病患者外周血干扰素诱导的T细胞α趋化因子(I-TAC)表达的影响。方法采用夹心酶联免疫吸附试验(ELISA)检测正常人和寻常性银屑病患者NB-UVB治疗前后外周血I-TAC水平变化。结果寻常性银屑病患者血清I-TAC水平明显高于正常对照组(t=21.37,P<0.05)。经NB-UVB治疗36次后,银屑病患者I-TAC水平较治疗前明显下降(t=18.23,P<0.05),且治疗前后银屑病患者银屑病皮损面积严重度指数(PASI)评分与血清I-TAC水平呈正相关(r=0.293,P<0.05)。结论 NB-UVB可降低寻常性银屑病患者外周血I-TAC水平,在银屑病的发病过程中I-TAC可能发挥重要作用。 Objective To study the effect of the narrow-band ultraviolet B（ NB-UVB） on serum levels of IFN-inducible T cell alpha chemoattractant（I-TAC） in psoriasis. Methods Sandwich enzyme-linked immunosorbent assay was used to detect peripheral blood levels of serum I-TAC in psoriasis vulgaris before and after the treatment of NB-UVB and healthy controls. Results The serum level of I-TAC was signifi cant higher in patients with psoriasis vulgaris than those in normal group（t=21.37, P0.05）. After the treatment of NB-UVB for 36 times, I-TAC level in psoriasis patients was signifi cantly decreased compared with before the treatment（t=18.23, P0.05）. PASI score of psoriasis patients, before and after the treatment, and serum I-TAC levels were positively correlated. Conclusion NB-UVB can reduce the serum level of I-TAC in patients with psoriasis vulgaris, and I-TAC may be involved in valueadded pathogenesis of psoriasis.
作者 樊卓 覃静净 王丹丹 党云
机构地区 西安医学院附属医院皮肤科
出处 《实用皮肤病学杂志》 2015年第2期92-94,共3页 Journal of Practical Dermatology
基金 陕西省教育厅专项科研计划项目(12JK0780)
关键词 银屑病 寻常性 中波紫外线 窄谱 T细胞α趋化因子 干扰素诱导 Psoriasis vulgaris Ultraviolet B narrow-band T cell alpha chemoattractant IFN-inducible
分类号 R758.63 [医药卫生—皮肤病学与性病学]
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参考文献9

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共引文献6

同被引文献64

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实用皮肤病学杂志
2015年 第2期

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