摘要
目的分析2型糖尿病(T2DM)合并视网膜病变(RD)患者的凝血功能。方法选择T2DM确诊患者154例,根据患者眼底检查结果分为无DR(NDR)组、DR组,DR组患者分为增殖性视网膜病变(PDR)组和非PDR(NPDR)组。采集所有患者一般资料,同时检测空腹血糖(FPG)、糖化血红蛋白A1c(HbA1c)、胆固醇(CHOL)、三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)、D-二聚体(DD)、纤维蛋白降解产物(FDP)等指标水平。对各研究组检测结果进行统计学分析。结果各研究组间FPG、HbA1c、CHOL、TG、HDL、LDL、PT、APTT、TT、DD、FDP水平比较差异无统计学意义(P>0.05)。DR组FIB水平高于NDR组(P<0.05),NPDR组、PDR组FIB水平比较差异无统计学意义(P>0.05)。结论糖尿病合并DR患者FIB水平升高,FIB可能在T2DM合并DR的发生、发展过程中起到一定的作用。
Objective To analysis the coagulation function in type 2diabetes mellitus（T2DM）patients with diabetic retinopathy（DR）.Methods A total of 154 cases of T2 DM patients were enrolled and divided into non-DR（NDR）group and DR group,which was further divided into proliferative diabetic retinopathy（PDR）group and nonPDR（NPDR）group,according to the results of fundus examination.Clinical data was recorded,and fasting blood glucose（FPG）,glycated haemoglobin A1c（HbA1c%）,cholesterol（CHOL）,triacylglycerol（TG）,high density lipoprotein（HDL）,low density lipoprotein（LDL）,prothrombin time（PT）,activated partial thromboplastin time（APTT）,thrombin time（TT）,fibrinogen（FIB）,D-dimer（DD）and fibrin degradation product（FDP）were detected and statistically analyzed.Results There were no statistical differences of FPG,HbA1 c,CHOL,TG,HDL,LDL,PT,APTT,TT,DD and FDP among the three groups（P〉0.05）.FIB level in DR group was higher than that in NDR group（P〈0.05）,but there was no statistical difference between NPDR group and PDR group（P〉0.05）.Conclusion FIB might be a risk factor for the onset of DR.More attention should be paid for the FIB level in T2 DM patients.
出处
《检验医学与临床》
CAS
2015年第7期885-887,共3页
Laboratory Medicine and Clinic
基金
国家高技术研究发展计划(2014AA022304)
首都卫生发展科研专项项目(2011-2008-02)
