摘要
目的探讨海洛因对人体肝肾功能的影响。方法对215例海洛因依赖者(研究组)及223例非药物成瘾的健康体检者(对照组)进行血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、谷氨酰转肽酶(GGT)、碱性磷酸酶(ALP)、血尿素氮(BUN)、肌酐(CR)、尿酸(UA)检测,并对结果进行比较。结果研究组ALT、AST、GGT、ALP水平均高于对照组,差异均有统计学意义(P<0.05)。研究组ALT、AST、GGT、ALP异常率分别为51.16%、36.74%、17.21%、19.07%,远高于对照组的4.48%、2.69%、1.79%、8.52%,差异均有统计学意义(P<0.05)。研究组血清BUN、CR、UA异常率与对照组比较,差异均无统计学意义(P>0.05)。结论海洛因依赖者血清ALT、AST、GGT、ALP等升高,提示肝功能受损。海洛因对机体肾功能影响不大,未造成损害。对于海洛因依赖者应定期监测肝功能。
Objective To explore the influence of heroin on human liver and kidney functions.Methods 215 cases of heroin addicts and 223 cases of non-drug-addiction healthy people were respectively selected as study group and control group.The serum levels of ALT,AST,GGT,ALP,BUN,CR,and UA of the two groups were detected,and the results were analyzed.Results The serum levels of ALT,AST,GGT and ALP in study group were significantly higher than those in control group（P〈0.05）.And the abnormal rates of the markers above in study group were 51.16%,36.74%,17.21% and 19.07% respectively,and those in control group were 4.48%,2.69%,1.79%and 8.52% respectively.There were difference between the two groups（P〈0.05）.There was no statistical difference of the abnormal rates of BUN,CR and UA between the two groups（P〉0.05）.Conclusion Heroin addicts have liver injury,however,heroin has small effect to kidney function.
出处
《检验医学与临床》
CAS
2015年第7期952-953,共2页
Laboratory Medicine and Clinic
关键词
海洛因
药物依赖
肝功能
肾功能
heroin
drug dependence
liver function
kidney function
