摘要
目的学习总结利妥昔单抗(美罗华,RTX)相关的间质性肺炎(RTX-IP)的疾病特点、发病机制及诊疗方法。方法通过相关检查并结合文献回顾,对2例在使用RTX治疗过程中发生IP的淋巴瘤患者进行病例分析及治疗。结果 2例患者在治疗后间质性肺炎病灶消失,后续原发病治疗过程顺利。结论 RTX-IP起病隐匿,病理机制不明,症状不典型,需引起临床医生重视。高分辨CT对其早期发现应用价值高,RTX增加了患者对机会菌的易感性可能是部分患者的发病机制。
We report two cases of rituximab（RTX）- induced interstitial pneumonia in two lymphoma patients receiving RTX treatment. Interstitial pneumonia was successfully managed in these two cases after a one- week- long intervention with corresponding treatments without affecting further treatment of the primary disease. RTX- induced interstitial pneumonia is characterized by a latent onset with an unclear pathological mechanism and absence of typical symptoms. High-resolution CT scan can provide valuable evidence for early diagnosis of RTX- induced interstitial pneumonia, which might be attributed partially to an increased susceptibility to P. jirovecii and fungal infection due to prolonged RTX treatment.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2015年第1期129-132,共4页
Journal of Southern Medical University
基金
国防科工委专项课题分题(B3320062101)
