摘要
目的：探讨孕妇牙周健康状况与早产发生的关系并分析相关高危因素。方法对162例早产孕妇（早产组）和150正常足月产妇（对照组）的牙周健康状况及生活习惯、社会因素进行统计，并对早产和牙周炎的关系进行分析；分别使用ELISA、免疫比浊法和放射免疫法对牙龈卟啉单胞菌的细胞表面抗原IgG（ Pg IgG）水平、血浆C反应蛋白（CRP）和白细胞介素－6（IL－6）及肿瘤坏死因子－α（TNF－α）进行测定。结果二元logistic模型发现早产与牙周炎之间有显著相关性（OR＝2．39，95％CI 1．26～4．52）。早产组和对照组在距离上次口腔科就诊时间（P＜0．05）、刷牙频率（P＜0．05）、吸烟习惯（P＜0．05）、每年是否常规进行口腔检查（P＜0．001）和孕检次数（ P＜0．001）方面差异有统计学意义。早产合并牙周炎孕妇血清中TNF－α、IL－6、CRP水平和Pg IgG滴度的光密度值均显著高于不合并牙周炎的对照组（ P＜0．05）；不合并牙周炎的孕妇中早产组IL－6显著高于对照组（ P＜0．05）。结论早产与牙周炎之间具有相关性，不良的口腔卫生习惯为牙周炎孕妇发生早产的高危因素。合并牙周炎的孕妇血浆炎性因子和Pg IgG的检测对早产的发生具有一定预测作用。
Objective To investigate the correlation between the oral health status and preterm , and thus to fur-ther analyze the related risk factors .Methods Oral health status and socioeconomic data were collected to analysis to the association between periodontitis and preterm .Pg IgG was tested by enzyme -linked immunosorbent assay （ELISA）.C-reactive protein（CRP） was tested by immunological transmission turbidimetry .The levels of interleukin -6（IL-6） and tumcr necrosis tactor-α（ TNF-α） were determined by radioimmunoassay .Results Significantly lengthened dental clin-ic visit interval, less dental and prenatal care frequencies , and lower brush frequency were observed in preterm group （P〈0.05）.According to binary logistic model, after adjusting for confounding variables , periodontitis was significantly as-sociated with preeclampsia （adjusted OR=2.39, 95%CI：1.26-4.52）.The levels of TNF-α, IL-6, CRP and Pg IgG were significantlyhigher in preterm patients complicated with periodontitis than that in control group （P〈0.05）.The levels of IL-6 was also significantly higher in preterm group than that in control group （ P〈0.05 ） .Conclusion Peri-odontitis is associated with preeclampsia .Poor oral health status is a risk factor of preterm .Maternal plasma inflammatory cytokines and Pg IgG test have predictive values on preterm in periodontitis patients .
出处
《广东医学》
CAS
北大核心
2015年第6期861-864,共4页
Guangdong Medical Journal
基金
广东省医学科研基金资助项目(编号:B2014025)
