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口腔鳞癌患者血清中骨桥蛋白(OPN)表达水平的研究 被引量：5

The expression level of OPN in serum of patients with oral squamous cell carcinoma
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摘要 ELISA试剂盒检测口腔鳞状细胞癌患者(58例)、颌面良性肿瘤患者(45例)及健康对照者(60例)血清中OPN的浓度(ng/ml)分别为161.8±12.6、52.3±8.6和48.6±12.8(P<0.05),在淋巴结转移、临床分期晚的患者血清中表达水平要显著高于未转移、临床分期早的患者(P<0.05),口腔鳞癌患者血清OPN与肿瘤的进展有关。 The concentration of osteopontin （OPN） in serum of patients with oral squamous cell carcinoma（ n =58 ）, benign maxillofacial tumor（ n =45） and healthy controls（ n = 60） was examined using ELISA kit. The OPN level（ng,/ml） in the 3 groups was 161.8 ± 12.6, 52.3 ± 8.6 and 48.6 ± 12.8 （ P 〈 0.05 ） respectively, the cases with nodal metastasis and late clinical stage have relatively higher expression levels of OPN（ P 〈0.05 ）. Serum OPN may be related to OSCC progression.
作者 许桓溪 白黎露 李宁男
机构地区 兰州石化总医院口腔科 兰州军区兰州总医院口腔科
出处 《实用口腔医学杂志》 CAS CSCD 北大核心 2015年第2期282-283,共2页 Journal of Practical Stomatology
关键词 口腔鳞状细胞癌 骨桥蛋白(OPN) TNM分期 Oral squamous cell carcinoma Osteopontin（ OPN） TNM stages
分类号 R739.8 [医药卫生—肿瘤]
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参考文献8

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  • 4潘淑婷,唐震,徐晓刚,周中华.骨桥蛋白与TIP30基因在口腔鳞癌中的表达[J].实用口腔医学杂志,2013,29(2):219-223. 被引量：1
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二级参考文献15

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实用口腔医学杂志
2015年 第2期

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