摘要
目的:探讨靶控输注不同效应室浓度的舒芬太尼复合丙泊酚对Narcotrend指数(NI)的影响。方法:选择60例全麻患者,年龄40-60岁,体重指数<30 kg/m2,ASAⅠ-Ⅱ级,随机分为4组(n=15):舒芬太尼效应室靶控浓度0.1 ng/m L(A组)、0.2 ng/m L(B组)、0.3 ng/m L(C组)、0.4 ng/m L(D组);各组舒芬太尼达效应室靶浓度5 min后给予丙泊酚1 mg/kg。记录实验过程中的血压、心率、血氧饱和度及NI。所有患者在实验结束后,均调整至适宜的麻醉深度,给与阿曲库胺,进行气管插管。结果:靶控输注舒芬太尼使各组的NI有不同程度的降低,随着靶控浓度的增加,降低幅度增大;单纯靶控输注舒芬太尼时,其效应室浓度与NI呈负相关,相关系数为-0.456。结论:舒芬太尼能降低NI,舒芬太尼效应室浓度与NI呈负相关。而舒芬太尼效应室浓度0.4 ng/m L复合丙泊酚后,NI反而呈短暂的上升,随后下降的现象。
Objective： To investigate the effects of different effect compartment of sufentanil combined with propofol by target controlled infusion on Narcotrend index. Methods： 60 patients, aged 40.-450, weight index〈30 kg/m2, ASA Ⅰ-Ⅱ undergoing general anes- thesia were randomly divided into 4 groups （n=l 5）： sufentanil effect compartment concentration 0.1 ng/mL （group A）, 0.2 ng/mL（group B）, 0.3 ngmL （group C）, and 0.4 ng/mL （group D）. The propofol of 1.0 mg/kg was administered after 5 min when the concentration of sufentanil reached the effect compartment concentration. The parameters of BP, FIR, SpO2 and Narcotrend index（NI） were recorded dur- ing proceeding of experiments. After experiments, all of patients were adjusted to appropriate anesthesia depth, then the muscle relaxants were administered and the tracheal intubations were done. Results： The NI decreased in varying degree with target injection of sufentanil, accompanied with the increase of target concentration, the trend of decrease is more obvious. During target-controlled infusion of sufen- tanil as sole, there was a negative correlation between the effect compartment concentration and NI, and the correlation index is -0.456. After 1 min of injecting propofol, the NI of Group D ascended initially, with statistical significance in comparison among groups （P〈0. 05）, then the Nil was decreased with the time. Conclusion： Sufentanil can decrease the NI, and the correlation between the effect com- partment concentration and NI is negative, while sufentanil of 0.4 ng/mL effect compartment concentration combined with propofol caused the phenomenon that the NI raised temporarily, whereafter decreased.
出处
《现代生物医学进展》
CAS
2015年第7期1290-1293,共4页
Progress in Modern Biomedicine
基金
黑龙江省科学基金重点项目(ZD201017)
关键词
舒芬太尼
靶控输注
效应室浓度
丙泊酚
Sufentanil
Targeted controlled injection
Effect compartment concentration
Propofol
