摘要
目的:探讨干燥综合征(ss)患者的唇腺活检病理表现、自身抗体及其在诊断中的意义。方法:收集85例干燥综合征患者的临床体征、唇腺活检以及其他相关辅助检查,对其唇腺活检病理标本及相关检查进行分析。结果:根据唇腺病理结果,单纯唇腺活检的阳性率为68.2%;单纯血清抗SSA/SSB抗体检出阳性率为78.8%;联合唇腺活检、抗SSA/SSB抗体疾病检出率达94.1%,与单纯唇腺活检或抗SSA/SSB抗体单项阳性的疾病检出率有统计学意义(P<0.05);并且唇腺活检阳性患者较阴性患者口干或眼干持续时间长(P<0.05);但腮腺ECT异常、关节肿痛、肺脏损害均较唇腺活检阴性组患者累及率高,但差异无统计学意义(P>0.05)。结论:唇腺活检、自身抗体是诊断干燥综合征的必要检查,而其联合应用更具有举足轻重的意义。
Objective： To explore their significance of lip histopathology and autoantibodies in diagnosis of Sjtigren＇s syndrome （ss）. Methods： We collected clinical signs,lip biopsies and other auxiliary examination of 85 patients with Sj^gren syndrome, lip biopsies and related inspections were analyzed. Results： According to the pathological changes of lip biopsy, the positive rate was 68.2% in 85 pa- tients. Single serum anti SSA/SSB antibody positive rate was 78.8%. Combined serum anti SSA/SSB antibody positive with lip histopath- ology can diagnose 94.1% patients of SS. It was statistically significant compared with simple labial gland biopsy or SSA/SSB single pos- itive （P〈0.05）. And labial gland biopsy positive patients had longer duration than negative patients with dry mouth or dry eyes （P〈0.05）. Those with pathological positive had slightly higher incidence of the parotid ECT, joint pain, and lung damage than the negative patients （P〉0.05）. Conclusions： Lip histopathotogy and autoantibodies are necessary to the diagnosis of ss, but the combined application has im- portant significance.
出处
《现代生物医学进展》
CAS
2015年第7期1307-1309,共3页
Progress in Modern Biomedicine
关键词
干燥综合征
唇腺病理
自身抗体
诊断
Sjogren＇s syndrome
Lip histopathology
Autoantibody
Diagnosis
