摘要
目的:检测S100A4在子宫内膜癌中的表达并分析其与子宫内膜癌临床病理指标的相关性,为子宫内膜癌的临床诊断、治疗及与预后预测提供参考依据。方法:采用免疫组织化学技术检测比较70例子宫内膜癌和40例正常子宫内膜组织中S100A4的表达,并分析子宫内膜癌组织中S100A4的表达与患者临床病理指标和生存期的相关性。结果:70例子宫内膜癌组织中S100A4的阳性表达率为57.14%(40/70),40例正常子宫内膜组织中S100A4的阳性表达率为10%(4/40),显著低于子宫内膜癌组织(P<0.05)。子宫内膜癌组织中S100A4的表达与患者的年龄和淋巴结转移无显著相关,但与肿块浸润子宫肌壁深度、分化程度、临床分期均呈显著相关(P<0.05)。S100A4呈阳性表达的子宫内膜癌患者的生存率和生存期均较S100A4呈阴性表达病例显著降低或缩短(P=0.01)。结论:子宫内膜癌组织中S100A4呈异常高表达,与子宫内膜癌的发生发展和预后密切相关,可能作为子宫内膜癌诊断和预后预测的参考标志物。
Objective： The aim of this study was to detect the expression of S100A4 in endometrial cancer and analyze its correlation with the clinicopathological features of endometrial cancer so as to provide references for the clinical diagnosis, treatment and prognostic prediction of endometrial cancer. Methods： The expression of S100A4 was detected by immunohistochemistry in 70 cases of endometrial carcinoma and 40 cases of normal endometrium, and the correlation of S 100A4 expression with clinical pathology index and survival was analyzed. Results： The positive rate of S 100A4 expression in 70 cases of endometrial carcinoma tissues was 57.14% （40/70）, which was significantly higher than that in 40 cases of normal endometrial tissue （10%, P〈0.05）. The expression of S100A4 had no significant correlation with the age and lymph node metastasis, but was significantly correlated with the tumor invasion depth of uterine muscle wall, differentiation degree and clinical stage （P〈0.05）. The survival rate and survival time of endometrial cancer with S 100A4 positive expression was markedly lower or shorter than those with S100A4 negative expression （P=0.01）. Conclusion： Abnormal upregulation of S100A4 expression was found in endometrial carcinoma and was closely related to the occurrence and prognostic prediction of endometrial carcinoma. S100A4 may be used as a marker of the diagnosis and prognosis ofendometrial cancer.
出处
《现代生物医学进展》
CAS
2015年第9期1681-1684,共4页
Progress in Modern Biomedicine
基金
湖南省科学技术厅科技计划项目(2010FJ3154)
