摘要
将金鸡纳生物碱衍生物用于催化蒽酮和β-硝基芳基乙烯的不对称Michael加成反应。考察了溶剂、温度及催化剂用量对反应催化性能的影响。结果表明,最佳条件为5%（摩尔分数）催化剂1b、甲苯为溶剂、0℃反应,得到了91%~99%的化学产率和最高达95%ee的对映体选择性。
Cinchona alkaloid derivatives as organocatalysts were applied in asymmetric Michael addition reaction of anthrone with various trans-β-nitroolefins. Solvent, temperature and catalyst loading were screened. The optimized conditions are using toluene as the solvent with a 5% （molar fraction） loading of catalyst lb at room temperature. The products are obtained in 91% -99% yield with up to 95% ee.
出处
《应用化学》
CAS
CSCD
北大核心
2015年第4期422-427,共6页
Chinese Journal of Applied Chemistry
基金
国家自然科学基金(21102055)
吉林省自然科学基金(201015237)资助项目~~
