摘要
目的探讨维生素K环氧化物还原酶亚单位1基因(vitamin K epoxide reductase complex 1,VKORC1)-1639G/A多态性与新疆地区维吾尔族、汉族心房颤动(简称房颤)的相关性。方法收集维吾尔族房颤患者100例,汉族102例,无房颤者维吾尔族103例,汉族111例,采用聚合酶链反应-限制性内切酶片段长度多态性方法检测VKORCl基因-1639G/A多态性。结果维吾尔族病例组和对照组VKORC1基因-1639G/A位点基因型分布及等位基因频率比较差异有统计学意义(P〈0.05),多因素Logistic回归分析显示VKORC1基因-1639G/A是维吾尔族房颤的独立危险因素之一(OR=2.085,95%CI:1.067~4.072,P=0.031);汉族病例组和对照组VKORC1基因-1639G/A位点基因型分布及等位基因频率比较差异无统计学意义(P〉0.05),多因素Logistic回归分析显示差异无统计学意义(P〉0.05);维吾尔族病例组与汉族病例组VKORC1基因-1639G/A位点基因型分布及等位基因频率比较差异有统计学意义(P〈0.05)。结论在新疆地区维吾尔族人群中,VKORC1基因-1639G/A多态性与房颤存在相关性,在汉族人群中,VKORC1基因-1639G/A多态性与房颤无相关性,维吾尔族与汉族房颤患者之间VKORC1基因-1639G/A多态性存在民族差异。
Objective To assess the association of VKORC1 gene -1639G/A polymorphism with atrial fibrillation (AF) in ethnic Uygurs and Hans from Xinjiang. Methods The above polymorphism was detected among 100 Uygur and 102 Han AF patients and 103 Uygur and 111 Han subjects that have no AF with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method, Results A statistically significant difference was detected between the patient and control groups of Uygur origin in terms of genotypic and allelic frequencies (P 〈 0. 05). Logistic regression analysis also indicated the -1639G/A polymorphism as an independent risk factor for AF in Uygur population (OR-~ 2. 085, 95 % CI: 1. 067-4. 072, P=0. 031). No similar statistical difference was found between the patient and control groups of Han origin (P〉0.05). Conclusion The -1639G/A polymorphism of VKORC1 gene is associated with AF in the Uygur population but not in Hans.
出处
《中华医学遗传学杂志》
CAS
CSCD
北大核心
2015年第2期264-268,共5页
Chinese Journal of Medical Genetics
基金
国家自然科学基金(81260037)