摘要
背景:可降解支架被认为是血管介入领域继球囊扩张血管成形、金属裸支架、药物洗脱支架后的第4次革新,镁合金支架是目前可降解支架的研发热点。目的:综述可降镁合金血管支架的研究现状,探讨其存在的缺点及研究应用趋势。方法:第一作者用计算机检索PubMed数据库、CNKI中国期刊全文数据库、万方全文数据库2001年1月至2014年11月收录的可降解镁合金血管支架相关研究内容,分析其研究现状及进展。结果与结论:镁合金作为可降解血管支架的体外研究集中在镁合金降解速度、生物相容性及镁合金对血管内皮细胞和平滑肌细胞的影响。目前的研究显示镁合金支架降解过快仍然是限制其大规模临床应用的主要原因,靶血管在置入支架后需要6-12个月的重建修复期,支架应在这段时间内提供机械支撑,现有的可降解镁合金支架尚难以达到这一要求。为提高镁合金支架的耐腐蚀性能及生物相容性,一方面可以考虑选择耐腐蚀性能更好的合金元素,另一方面通过支架涂层等表面改性技术来提高支架的抗腐蚀性能与生物相容性,也是未来镁合金支架研发的一大趋势。
BACKGROUND：Biodegradable stents are regarded as the fourth revolution in the interventional cardiology after the invention of baloon angioplasty, bare metal stents, and drug-eluting stents. Biodegradable magnesium aloy stent is the focus of biodegradable stent research. OBJECTIVE：To summarize the application status of biodegradable magnesium aloy stents and to discuss the existing shortcomings and research trends. METHODS： A computer-based retrieval of PubMed, CNKI and Wanfang databases between January 2001 and November 2014 was performed by the first author, to analyze the research progress about biodegradable magnesium aloy stents. RESULTS AND CONCLUSION： Studies on biodegradable magnesium aloy stentin vitro is focused on the magnesium aloy degradation speed, biocompatibility, and its effects on vascular endothelial cels and smooth muscle cels. The present findings have shown that the main reason restricts the large-scale clinical application of magnesium aloy stents is the excessive degradation speed. It takes 6-12 months to reconstruction for target vessels after stent implantation. During this period, the stent is expected to provide mechanical support. The existing biodegradable magnesium aloy stents cannot meet this requirement. In order to improve the corrosion resistance ability of magnesium aloy stents, on the one hand, we can consider
to seek new aloy elements that posses better corrosion resistance ability; on the other hand, using surface modification techniques such as stent coating to improve the corrosion resistance ability and biocompatibility is a trend of future research and development of magnesium aloy stents.
出处
《中国组织工程研究》
CAS
北大核心
2015年第8期1284-1288,共5页
Chinese Journal of Tissue Engineering Research
