摘要
目的：观察单唾液酸四己糖神经节苷脂（ GM1）对青光眼术后视神经的保护作用。方法选取2012年10月～2013年10月在本院治疗的60例青光眼患者的临床资料，分为对照组和治疗组，对照组予以手术联合术后静脉推注甲钴胺注射液治疗（每次1．0mg，每日1次），连续2周后改口服甲钴胺糖衣片0．5mg，3次／d，连续3个月。治疗组在对照组的基础上，术后联合应用GM180mg＋5％葡萄糖溶液250ml静脉滴注，每日1次，连用2周，然后改为40mg＋5％葡萄糖溶液250ml静脉滴注，每日1次，连用2周，随访3个月。所有患者在治疗前、治疗后1周、2周、4周、3个月均行OCT视神经检查及视野检查。结果对照组和治疗组患者的治疗前一般情况无明显差异，对照组的28例患者中无改善12例，有效16例，总有效率57．74％；治疗组的32例患者中视力无效3例，有效29例，总有效率92．16％，视力恢复程度优于对照组（P＜0．05）。结论尽早行抗青光眼手术治疗对减轻视神经的损伤起关键作用，联合应用GM1可保护视神经功能，减小患者视力损伤，且安全性良好。
Objective To observe the protective effect of Monosialotetrahexosylganglioside （GM1）on optic nerve which was dam-aged by glaucoma .Methods Sixty glaucoma cases in our hospital from October of 2012 to October of 2013 were divided into control group and treatment group.The control group were treated by glaucoma surgery combined with mecobalamin injection 1.0mg/d,im for 2 weeks,and then mecobalamin tablets 1.5mg/d,po for 3 months.On the basis of the control group,32 cases were treated by using GM1 80mg＋5%GS 250ml/d,ivgtt for 2 weeks and then GM1 40mg＋5%GS 250ml/d,ivgtt for 2 weeks.Follow-up for 3 months.All of the patients had OCT op-tic nerve and visual field tested before treatment and 1 week,2 weeks,4 weeks,3 months after treatment.Results Before the treatment,two groups had no obvious difference .Among the 28 cases in the control group,no improvement were 12 cases,16 cases were effective,the total effective rate was 57.74%.In the treatment group ,no improvement was 3 cases and the total effective rate was 92.16%.The effective rate and the visual acuity were better than those in the control group .Conclusion Conduction of glaucoma surgery as soon as possible play a key role in easing the optic nerve injury .Glaucoma surgery combined with GM 1 can significantly protect the optic nerve function ,improve eyesight and its security is good .
出处
《潍坊医学院学报》
2015年第1期64-66,共3页
Acta Academiae Medicinae Weifang
