摘要
背景:创面愈合是外科学研究的热点。结缔组织生长因子参与调节皮肤创面愈合过程并发挥了重要作用。目的:综述结缔组织生长因子在创面中的表达规律及其在瘢痕愈合和创面愈合中的作用。方法:运用计算机检索中国CNKI学术总库(www.cnki.net)、万方数据库、维普中文科技期刊数据库、Springer Link及Pub Med数据库相关文章。以"结缔组织生长因子;瘢痕;创面愈合;再生"为中文检索词;以"CTGF;CCN2;Wound healing;Regeneration"为英文检索词。纳入37篇关于结缔组织生长因子的基础研究及其在创面愈合实验中相关研究进行讨论。结果与结论:结缔组织生长因子在皮肤创面愈合及瘢痕形成过程中呈动态表达。在创伤修复初期,结缔组织生长因子的短暂上调可促进肉芽组织和新生血管形成等加速创面修复过程;在伤口修复和重塑阶段的持续表达可明显促进过度基质的产生、胶原沉积和瘢痕挛缩,导致病理性瘢痕的发生。结缔组织生长因子参与了皮肤创面的愈合过程,其在加速创面愈合和控制瘢痕形成方面可能具有应用前景。结缔组织生长因子作为转化生长因子β的下游产物,除本身的生物学作用外,其介导转化生长因子β的促成纤维细胞增殖、促纤维化、诱导黏附及迁移等作用是其影响创面愈合的作用机制之一。
BACKGROUND：The wound healing is the hot topic in the research of surgery. Connective tissue growth factor plays an important role in the regulation of wound healing.
OBJECTIVE：To review the current development of connective tissue growth factor in wound healing, and to investigate the mechanism. METHODS：The CNKI database, WANFANG database, VIP database, Springer Link database and PubMed database were retrieved for the related articles with the key words of“CTGF;CCN2;scar;wound healing;regeneration”in English and Chinese, respectively. A total of 37 articles related to the basic study of connective tissue growth factor involved in the regulation of wound healing were included.RESULTS AND CONCLUSION：Connective tissue growth factor has dynamic expression in skin wound healing and scar formation. In the early stage of wound repair, the transient up-regulation of connective tissue growth factor can accelerate the wound healing by promoting the formation of granulation tissue and new blood vessels, while its sustained expression in wound repair and remodeling phases can promote excessive produce of matrixes, col agen deposition and scar contracture, thereby leading to the formation of pathologic scars. Connective tissue growth factors are involved in the skin wound healing, which have broad application prospects in accelerating wound healing and inhibiting scar formation. Connective tissue growth factor as the downstream product of transforming growth factor-β, in addition to its own biological role, can mediate transforming growth factorβcontributing to the proliferation of fibroblasts, promoting fibrosis, induced adhesion and migration, which is one of its mechanisms underlying the effects on wound healing.
出处
《中国组织工程研究》
CAS
北大核心
2015年第7期1042-1046,共5页
Chinese Journal of Tissue Engineering Research
基金
甘肃省自然科学基金(1107RJZA207)
甘肃省卫生行业科研计划(GSWT09~7)~~
