摘要
在相同条件下,α-萘乙酸分别与二丁基氧化锡、氧化双(三丁基锡)反应,合成了四核簇状二丁基锡α-萘乙酸酯{[n-Bu2Sn(O2CCH2C10H7)]2O}2(1)和一维链状三丁基锡α-萘乙酸酯[n-Bu3Sn(O2CCH2C10H7)]n(2)。经IR、1H和13C NMR、元素分析和X-射线单晶衍射表征结构。1具有核心结构为氧原子桥联锡构筑的Sn2O2四元环,且四元环二聚形成Sn4O4簇状,中间Sn2O2环的中心为整个分子的对称中心。1中,两相邻配合物分子间通过C-H…π作用、形成一维带状结构。配合物2中,锡原子通过羧基双齿桥联、组成一维链状配位聚合物。测试表明:1和2分别在250、175℃以下可以稳定存在;对人癌细胞Colo205、Hep G2、MCF-7、Hela、NCI-H460增殖均有较强的抑制作用,且2的活性高于1。
The tetra-nuclear cluster dibutyltin α-naphthaleneacetic carboxylate {[n-Bu2Sn（O2CCH2C10H7）]2O}2（1）and the 1D chain tributyltin α-naphthaleneacetic carboxylate [n-Bu3Sn（O2CCH2C10H7）]n（2） were synthesized by the reactions of α-naphthaleneacetic acid with dibutyltin oxide and bis（tributyltin） oxide under the same conditions,respectively. Their structures were characterized by IR,1H and13 C NMR, elemental analysis and X-ray crystal diffraction. The core structures of 1 are two Sn2O2four-membered rings which are constructed of Sn atoms with O bridges, and the two Sn2O2 units are dimerized to a Sn4O4 cluster, so the center of central Sn2O2 ring coincides with the symmetry center of whole molecule. Due to the C-H …π interactions, the adjacent molecules of complex1 is linked to generate 1D ribbon structure. For complex 2, two Sn atoms are bridged by two O atoms of a carboxylate ligand to form 1D infinite chain coordination polymer. Thermogravimetric analysis shows the complexes were stable up to 250 or 175 ℃, respectively. Moreover, the tests showed that both of them displayed strong in vitro anti-tumor activity against five human tumor cell lines, Colo205, Hep G2, MCF-7, Hela and NCIH460, but the activity order is 21. CCDC： 1026774, 1; 1026775, 2.
出处
《无机化学学报》
SCIE
CAS
CSCD
北大核心
2015年第4期710-716,共7页
Chinese Journal of Inorganic Chemistry
基金
湖南省自然科学基金(No.13JJ3112)
湖南省科技计划(No.2014NK3086)
湖南省高校创新平台开放基金(No.13K105,14K014,GN14K01)
衡阳师范学院协同创新中心培育项目(No.12XT02)
青年骨干教师培养计划(2012)
国家级大学生创业训练计划(No.201310546127)
湖南省大学生研究性学习项目(No.CX1301)资助项目
关键词
有机锡
溶剂热合成
晶体结构
抗癌活性
organotin
solvothermal synthesis
crystal structure
anti-tumor activity
