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GP78基因多态性与冠心病相关 被引量：3

GP78 gene polymorphism is associated with coronary heart disease
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摘要 目的探讨GP78基因多态性与冠心病的相关性。方法TaqManSNP基因分型法对1109例（557例冠心病患者＋552例对照者）无血缘关系的研究对象进行基因分型，并应用病例对照的研究方法进行相关性分析。结果GP78基因rs2617849位点的基因分型和等位基因频率在冠心病组和对照组之间的分布存在明显差异（P〈0．05），冠心病组携带，TT基因型（TTvsCC＋CT）和T等位基因高于对照组（P〈0．05），在排除吸烟、高血压、糖尿病和低密度脂蛋白胆固醇等混杂因素后，仍存在显著性差异（95％CI：1．035-1．736，P〈0．05）。结论GP78基因的rs2617849位点多态性与冠心病相关，rs2617849的TT基因型和T等位基因可作为冠心病易感基因标记。 Objective To evaluate potential association between human GP78 gene and coronary heart disease （CHD）. Methods The genotype was analyzed with by a Real-time PCR instrument in CHD group （n = 557） and control group（n =552）. The data were evaluated via case control study. Results The distribution of rs2617849 genotype and allele frequency showed significant difference between CHD and control subjects（P 〈 0.05 ） ,the dis- tribution of the TY genotype and T allele was significantly higher in CHD patients than control subjects（ P 〈 0. 05 ）. The significance of the TT genotype between CHD patients and control subjects retained after adjustment for covari- ates （ 95% CI ： 1. 035 - 1. 736, P 〈 0. 05 ）. Conclusions rs2617849 polymorphism is closely associated with CHD,Tr genotype and T allele of rs2617849 functions as a genetic marker of CHD.
作者 查额尔敦巴特 付真彦 董春岚 王蓓 黄定
机构地区 新疆医科大学第一附属医院心脏中心冠心病科
出处 《基础医学与临床》 CSCD 2015年第4期450-453,共4页 Basic and Clinical Medicine
基金 国家自然科学基金(81260041) 新疆维吾尔自治区科技支疆项目(2013911111)
关键词 GP78 单核苷酸多态性 病例对照 冠心病 GP78 single nucleotide polymorphism case-control study coronary heart disease
分类号 R541.4 [医药卫生—心血管疾病]
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同被引文献21

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基础医学与临床
2015年 第4期

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