摘要
端粒缩短是遗传性或获得性骨髓衰竭的共同途径之一。基因突变导致端粒缩短,减少造血干细胞数量和增殖能力,导致骨髓低增生。环境因素打破代偿造血平衡,导致骨髓衰竭。
Telomere shortening is one of the common ways to hereditary or acquired bone marrow failure. Telomere short- ening caused by gene mutations reduces the number and proliferation of hematopoietic stem cells, and leads to bone mar- row hypoplasia. Environmental factors break compensatory hematopoietic balance and lead to bone marrow failure.
出处
《基础医学与临床》
CSCD
2015年第4期545-548,共4页
Basic and Clinical Medicine
基金
诺华铁过载基金(2013)
中国抗癌协会一百时美施贵宝血液肿瘤科研发展专项基金提供学术支持
关键词
端粒
端粒酶
骨髓衰竭性疾病
telomere
telomerase
bone marrow failure diseases
