摘要
目前,所有的常规抗生素都出现了相应的抗药性致病菌株,病原菌的抗药性问题已经日益严重地威胁着人们的健康。开发全新类型的抗生素是解决抗药性问题的一条有效途径。抗菌肽具有广谱抗菌性、抗菌活性高、种类多等优点,成为传统抗生素的理想替代药物。抗菌肽的来源非常广泛,如植物、动物、微生物等;不同抗菌肽的作用机制及其研究方法也有显著的差异。本文就抗菌肽的制备、抗菌机制和研究抗菌机制的方法做一概述。
Currently,all the conventional antibiotics have developed corresponding drug-resistant pathogenic strains,which have increasingly become a serious threat to people′s health.Development of completely new types of antibiotics is one of effective ways to solve the drug resistance issue.Antimicrobial peptides with broad-spectrum antibacterial and antimicrobial activity and wild variety become the ideal alternative to traditional antibiotics.Antimicrobial peptides are derived from wide range of sources,such as plants,animals,and microorganisms.Mechanism of function of the antimicrobial peptides and the investigation approaches of different antimicrobial peptides also vary dramatically.In this paper,we give an overview of preparation,antibacterial mechanisms,and research methodology of antimicrobial peptides.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2015年第2期465-469,共5页
Journal of Biomedical Engineering
关键词
抗菌肽
抗菌机制
细胞膜
antimicrobial peptides
antibacterial mechanisms
cell membranes
